Volume 30, Issue 192 (1-2021)
J Mazandaran Univ Med Sci 2021, 30(192): 133-138 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Azizzadeh Delshad A, Badkoobeh Hazaveh Z, Jalali Nadoushan M. CD117 Expression in Multinodular Goiter and Papillary Thyroid Carcinoma and Its Association with Prognostic Factors. J Mazandaran Univ Med Sci 2021; 30 (192) :133-138
URL: http://jmums.mazums.ac.ir/article-1-15191-en.html
URL: http://jmums.mazums.ac.ir/article-1-15191-en.html
Abstract: (1290 Views)
Background and purpose: Multinodular goiter is a benign enlargement of thyroid gland and papillary thyroid carcinoma is the most common type of thyroid cancer. Today, immunohistochemical markers can be used in diagnosis and prognosis of tumors. The aim of this study was to compare the expression of CD117 in multinodular goiter and papillary thyroid carcinoma and its association with prognostic factors.
Materials and methods: In this cross-sectional study, samples of thyroid tissue from
60 multinodular goiter and 60 papillary thyroid carcinoma cases who underwent thyroidectomy in
Tehran Mostafa Khomeini Hospital during 2011-18, were evaluated for CD117 expression via immunohistochemistry. The expression intensity was scored 0-3.
Results: CD117 was expressed in all samples with generally lower expression scores in malignant samples: 95% and 5% of malignant cases showed scores 1 and 2, respectively. Almost 52% and 48% of benign cases showed score 1 and scores 2 and 3, respectively (P<0.05). Increased CD117 expression was associated with decreased lymph node involvement and increased tumor size (P<0.05), but there was no significant relationship between this marker and other prognostic variables (P=0.081).
Conclusion: There are contradictory findings on the relation between CD117 expression
and prognostic factors in malignant cases, therefore, further studies are recommended to clarify the association.
Materials and methods: In this cross-sectional study, samples of thyroid tissue from
60 multinodular goiter and 60 papillary thyroid carcinoma cases who underwent thyroidectomy in
Tehran Mostafa Khomeini Hospital during 2011-18, were evaluated for CD117 expression via immunohistochemistry. The expression intensity was scored 0-3.
Results: CD117 was expressed in all samples with generally lower expression scores in malignant samples: 95% and 5% of malignant cases showed scores 1 and 2, respectively. Almost 52% and 48% of benign cases showed score 1 and scores 2 and 3, respectively (P<0.05). Increased CD117 expression was associated with decreased lymph node involvement and increased tumor size (P<0.05), but there was no significant relationship between this marker and other prognostic variables (P=0.081).
Conclusion: There are contradictory findings on the relation between CD117 expression
and prognostic factors in malignant cases, therefore, further studies are recommended to clarify the association.
Type of Study: Brief Report |
Subject:
Pathology
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
