Volume 31, Issue 196 (5-2021)
J Mazandaran Univ Med Sci 2021, 31(196): 136-142 |
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Raeeszadeh M, Heidari R, Khademi N. Effect of Sumac (Rhus coriaria L.) Aqueous Extract on Liver Enzymes and Anxious Behavior Caused by Lead Poisoning in Rat. J Mazandaran Univ Med Sci 2021; 31 (196) :136-142
URL: http://jmums.mazums.ac.ir/article-1-15366-en.html
URL: http://jmums.mazums.ac.ir/article-1-15366-en.html
Abstract: (1263 Views)
Background and purpose: Controlling the toxic effects of lead in biological systems is highly important. This study investigated the effect of sumac (Rhus coriaria L.) aqueous extract on liver enzymes in lead poisoning and behavioral changes in rats.
Materials and methods: This interventional study was performed in 7 groups of rats: control, drinking lead acetate at 500, 1000 and 1500 ppm, sumac aqueous extract 250 mg/kg and lead acetate in drinking water for 29 days. On the last day, after weighing, elevated plus-maze (EPM) test was performed. The serum was separated to measure Total Antioxidant Capacity (TAC), Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate transaminase (AST). Malondialdehyde (MDA) concentrations in liver and brain tissues were also determined.
Results: The highest average weight at the end, was seen in the group that received 1500 ppm lead acetate. The highest concentrations of liver and brain MDA were observed also in this group (18.0 ± 6.766 and 15.43 ± 0.432μmol /ml, respectively) which was higher compared to the control group, 500ppm lead group, and the extract group (P<0.01). The greatest and lowest TAC were found in the control group (333.00 ± 22.204 μmol/ml) and the 1500 ppm lead group (96.96 ± 6.669 μmol/ml), respectively (P<0.01). The ALT and AST concentrations were low in the control group and high in the 1500 ppm lead group. The minimum time passed in the open arm in the 1500 ppm lead group was 14.42%±8.247 which was lower compared to the control group (P <0.01).
Conclusion: In current study, sumac aqueous extract reduced the concentrations of liver enzymes in lead poisoning conditions. However, it had no significant effect on controlling lead induced anxiety.
Materials and methods: This interventional study was performed in 7 groups of rats: control, drinking lead acetate at 500, 1000 and 1500 ppm, sumac aqueous extract 250 mg/kg and lead acetate in drinking water for 29 days. On the last day, after weighing, elevated plus-maze (EPM) test was performed. The serum was separated to measure Total Antioxidant Capacity (TAC), Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate transaminase (AST). Malondialdehyde (MDA) concentrations in liver and brain tissues were also determined.
Results: The highest average weight at the end, was seen in the group that received 1500 ppm lead acetate. The highest concentrations of liver and brain MDA were observed also in this group (18.0 ± 6.766 and 15.43 ± 0.432μmol /ml, respectively) which was higher compared to the control group, 500ppm lead group, and the extract group (P<0.01). The greatest and lowest TAC were found in the control group (333.00 ± 22.204 μmol/ml) and the 1500 ppm lead group (96.96 ± 6.669 μmol/ml), respectively (P<0.01). The ALT and AST concentrations were low in the control group and high in the 1500 ppm lead group. The minimum time passed in the open arm in the 1500 ppm lead group was 14.42%±8.247 which was lower compared to the control group (P <0.01).
Conclusion: In current study, sumac aqueous extract reduced the concentrations of liver enzymes in lead poisoning conditions. However, it had no significant effect on controlling lead induced anxiety.
Type of Study: Brief Report |
Subject:
pharmacology
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