Volume 31, Issue 204 (1-2022)
J Mazandaran Univ Med Sci 2022, 31(204): 40-48 |
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Seifi S, Mosaedi M, Mohahammadpour A, Nouri H R, Bijani A. Association between XRCC1 (rs1799782) Gene Polymorphism and Oral squamous cell carcinoma. J Mazandaran Univ Med Sci 2022; 31 (204) :40-48
URL: http://jmums.mazums.ac.ir/article-1-16451-en.html
URL: http://jmums.mazums.ac.ir/article-1-16451-en.html
Abstract: (964 Views)
Background and purpose: Oral squamous cell carcinoma (OSCC) is the most common tumor of the head and neck. XRCC1 is a DNA repair gene and there are controversies about the association between XRCC1 gene polymorphism (RS1799782) in pathogenesis and susceptibility to OSCC. The purpose of this study was to investigate the association between XRCC1 (rs1799782) gene polymorphism and its dominant allele frequency in OSCC patients and healthy subjects.
Materials and methods: In this case-control study, 50 patients and 59 healthy individuals enrolled. Paraffin blocks of patients with OSCC were used to prepare 5-10 µm sections and 5 cc peripheral blood were collected from healthy individuals. Genomic DNA was extracted and evaluated using the PCR-restriction fragment length polymorphism (RFLP).
Results: There was a significant difference in the allele and genotype frequency of XRCC1 (rs1799782) between patients with OSCC and control individuals (X2 = 6.530, P = 0.0342). Frequency of T allele was 34% and 19% in OSCC patients and control group, respectively (OR= 2.1962, P= 0.0175). Smoking was strongly associated with TT genotype (OR=20.65: 95% CI: 4.49-10.1)
Conclusion: According to this study, XRCC1 (rs1799782) is effective in pathogenesis of OSCC and the TT genotype has a role in susceptibility to OSCC.
Materials and methods: In this case-control study, 50 patients and 59 healthy individuals enrolled. Paraffin blocks of patients with OSCC were used to prepare 5-10 µm sections and 5 cc peripheral blood were collected from healthy individuals. Genomic DNA was extracted and evaluated using the PCR-restriction fragment length polymorphism (RFLP).
Results: There was a significant difference in the allele and genotype frequency of XRCC1 (rs1799782) between patients with OSCC and control individuals (X2 = 6.530, P = 0.0342). Frequency of T allele was 34% and 19% in OSCC patients and control group, respectively (OR= 2.1962, P= 0.0175). Smoking was strongly associated with TT genotype (OR=20.65: 95% CI: 4.49-10.1)
Conclusion: According to this study, XRCC1 (rs1799782) is effective in pathogenesis of OSCC and the TT genotype has a role in susceptibility to OSCC.
Keywords: single nucleotide polymorphism, rs1799782, XRCC1, Oral squamous cell carcinoma, polymerase chain reaction
Type of Study: Research(Original) |
Subject:
Oral and maxillofacial pathology
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