Volume 33, Issue 2 (12-2023)
J Mazandaran Univ Med Sci 2023, 33(2): 96-105 |
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Bahar A, Mehravaran S H, Kashi Z, Abedi S, Mohammadpour Tahamtan R A, Safari F. Investigation of the Association of Metformin Consumption with Disease Severity, Inflammatory Markers, and the Outcome of COVID-19 in Diabetic Patients Hospitalized Due to COVID-19 in Imam Khomeini Hospital, Sari, 2019. J Mazandaran Univ Med Sci 2023; 33 (2) :96-105
URL: http://jmums.mazums.ac.ir/article-1-19439-en.html
URL: http://jmums.mazums.ac.ir/article-1-19439-en.html
Adele Bahar 
, Seyyed Hossein Mehravaran , Zahra Kashi , Siavash Abedi , Reza Ali Mohammadpour Tahamtan , Fateme Safari
, Seyyed Hossein Mehravaran , Zahra Kashi , Siavash Abedi , Reza Ali Mohammadpour Tahamtan , Fateme Safari
Abstract: (314 Views)
Background and purpose: The present study investigated the association of Metformin use with disease severity, inflammatory markers, and the outcome of COVID-19 in hospitalized diabetic COVID-19 patients at Imam Khomeini Hospital, Sari, in 2021.
Materials and methods: The current descriptive study was performed after obtaining the code of ethics and permission from the hospital director for the medical records evaluation. The relevant data of diabetic COVID-19 patients admitted at Imam Khomeini Medical Education Center were determined and analyzed using SPSS software.
Results: In this study, 324 patients were included in the study; So that 168 people (51.85%) were men and 156 people (48.15%) were women. The difference in the number of people with and without metformin use in the need to be admitted to the special care unit was statistically significant (P<0.0001). The difference in the number of people with and without metformin use in the final outcome of the disease was statistically significant (P<0.0001). the difference in the number of people needing invasive ventilation according to metformin consumption was not statistically significant. (P= 0.056).
Conclusion: In conclusion, our findings revealed that Metformin could have positive effects on the rate of ICU admission, need for mechanical ventilatory support, N/L ratio, and mortality in diabetic patients hospitalized for COVID-19 infection.
Materials and methods: The current descriptive study was performed after obtaining the code of ethics and permission from the hospital director for the medical records evaluation. The relevant data of diabetic COVID-19 patients admitted at Imam Khomeini Medical Education Center were determined and analyzed using SPSS software.
Results: In this study, 324 patients were included in the study; So that 168 people (51.85%) were men and 156 people (48.15%) were women. The difference in the number of people with and without metformin use in the need to be admitted to the special care unit was statistically significant (P<0.0001). The difference in the number of people with and without metformin use in the final outcome of the disease was statistically significant (P<0.0001). the difference in the number of people needing invasive ventilation according to metformin consumption was not statistically significant. (P= 0.056).
Conclusion: In conclusion, our findings revealed that Metformin could have positive effects on the rate of ICU admission, need for mechanical ventilatory support, N/L ratio, and mortality in diabetic patients hospitalized for COVID-19 infection.
Type of Study: Research(Original) |
Subject:
Endocrine diseases
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