Volume 33, Issue 2 (12-2023)                   J Mazandaran Univ Med Sci 2023, 33(2): 96-105 | Back to browse issues page

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Abstract:   (301 Views)
Background and purpose: The present study investigated the association of Metformin use with disease severity, inflammatory markers, and the outcome of COVID-19 in hospitalized diabetic COVID-19 patients at Imam Khomeini Hospital, Sari, in 2021.
Materials and methods: The current descriptive study was performed after obtaining the code of ethics and permission from the hospital director for the medical records evaluation. The relevant data of diabetic COVID-19 patients admitted at Imam Khomeini Medical Education Center were determined and analyzed using SPSS software.
Results: In this study, 324 patients were included in the study; So that 168 people (51.85%) were men and 156 people (48.15%) were women. The difference in the number of people with and without metformin use in the need to be admitted to the special care unit was statistically significant (P<0.0001). The difference in the number of people with and without metformin use in the final outcome of the disease was statistically significant (P<0.0001). the difference in the number of people needing invasive ventilation according to metformin consumption was not statistically significant. (P= 0.056).
Conclusion: In conclusion, our findings revealed that Metformin could have positive effects on the rate of ICU admission, need for mechanical ventilatory support, N/L ratio, and mortality in diabetic patients hospitalized for COVID-19 infection.
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Type of Study: Research(Original) | Subject: Endocrine diseases

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