Background and purpose: Parkinson 's disease, one of the most common neuromotor disorders, is caused by the progressive destruction of the dopaminergic neurons of the basal nuclei. Whey is considered a rich source of amino acids and peptides with biological properties. Considering the beneficial effects of exercise on the inhibition and recovery of neuronal damage, the present study investigated the effect of swimming exercise and whey administration on motor dysfunction and gene expression of apoptotic factors of the striatumin the Parkinson's disease model induced with retenon.
Materials and methods: 13-15-month-old male Wistar rats were used. Daily injections of rotenone (2.5 mg/kg in 5% DMSO; i.p.) for 60 days were used to induce PD. 24 h after the last injection, muscle stiffness was measured using the bar test and grid test. Bradykinesia was measured by the rearing behavior. Whey (4 g/rat) was administered daily by gavage for 30 days. Swimming exercise were performed daily for 15 min for 30 days (5 minutes swimming, repeated 3 times at 10-minute intervals). Afterwards, themotor skills were measured again. Striatum tissue was then isolated and stored at -80° C. Real-time PCR was used for the expression of caspases 3 and 6.Rights and permissions | |
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