Volume 33, Issue 2 (12-2023)                   J Mazandaran Univ Med Sci 2023, 33(2): 303-308 | Back to browse issues page

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Rahimzadeh G, Valadan R, Shariatniya M, Ahanjan M. Investigation the Frequency of Metallo-Beta-Lactamase-Producing Microbial Resistance Genes in Pseudomonas Aeruginosa Isolates in Zare Burn and Psychiatric Hospital, Sari. J Mazandaran Univ Med Sci 2023; 33 (2) :303-308
URL: http://jmums.mazums.ac.ir/article-1-20198-en.html
Abstract:   (363 Views)
Background and purpose: Pseudomonas aeruginosa is a significant contributor to hospital-acquired infections, including urinary infections, bacteremia, pneumonia, and burn wound infections. Due to the significant role of carbapenems in treating infections that are resistant to conventional antibiotics, it is necessary to identify the prevalence and resistance patterns of pathogens that cause hospital infections. This will help to prevent the spread of microbial resistance, and subsequently, reduce the death rate caused by such infections. Therefore, the aim of the present study is to determine the occurrence of metallo-beta-lactamase genes in Pseudomonas aeruginosa isolates in Sari hospitals.
Materials and methods: This cross-sectional study included 150 isolates of Pseudomonas aeruginosa as clinical samples that were collected from patients from the burn department of Zare Hospital, Sari city. To determine the antibiotic sensitivity, the disk diffusion method was used. Additionally, PCR method was employed to examine the prevalence of beta-lactamase genes blaVIM-1 and blaIMP-1 in the isolates.
Results: Based on the antibiotic sensitivity results, it was found that the highest resistance was observed to gentamicin, ceftazidime, imipenem, ciprofloxacin, amikacin, meropenem, cefepime, ceftriaxone, and calcitin. The data analysis also revealed that the frequencies of blaVIM-1 and bla IMP-1 genes were detected in isolates of 45% and 55%, respectively.
Conclusion: The frequency of Pseudomonas aeruginosa strains carrying the MBLs genes is increasing in Zare Hospital in Sari. The findings of the study strongly suggest that there is necessary to prevent the experimental and indiscriminate administration of carbapenems in intensive care and burn departments of hospitals.
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Type of Study: Brief Report | Subject: Microbiology

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