Volume 36, Issue 260 (9-2026)
J Mazandaran Univ Med Sci 2026, 36(260): 18-29 |
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Entezari Moghaddam N, Almarhoon B, Aghaali M, Saleh A, Mehdipour A. Comparison of Silver Diamine Fluoride and Sodium Fluoride Varnish on Salivary pH, Caries Arrest in Primary Teeth, and Parental Acceptance: A Randomized Clinical Trial. J Mazandaran Univ Med Sci 2026; 36 (260) :18-29
URL: http://jmums.mazums.ac.ir/article-1-22844-en.html
URL: http://jmums.mazums.ac.ir/article-1-22844-en.html
Abstract: (18 Views)
Background and purpose: Early childhood caries (ECC) is a highly prevalent condition that can progress rapidly, particularly in young children with limited ability to cooperate during dental treatment. Non-invasive fluoride-based therapies, such as silver diamine fluoride (SDF) and sodium fluoride (NaF) varnish, are used to manage early carious lesions. This study aimed to compare the effects of 38% SDF and 5% NaF varnish on salivary pH, caries arrest in primary teeth, and parental acceptance.
Materials and methods: In this randomized, single-blind clinical trial, 60 children aged 6–10 years with active non-cavitated or superficially cavitated carious lesions (ICDAS codes 1-3) were randomly assigned to receive either 38% SDF or 5% NaF varnish. Unstimulated salivary pH was measured at baseline and one week after treatment. Caries arrest was clinically evaluated after three months. Parental acceptance of SDF was assessed using a Likert-scale questionnaire. Statistical analyses included paired and independent t-tests and chi-square tests.
Results: Salivary pH increased significantly in both groups one week after treatment (P< 0.001), with a significantly greater increase in the SDF group. Caries arrest was observed in 96.7% of lesions in the SDF group and 90.0% in the NaF group, with no statistically significant difference between groups (P= 0.301). All parents rated SDF application as painless and easy to administer, and reported acceptable taste and discoloration.
Conclusion: Both SDF and NaF varnish were effective in arresting caries in primary teeth. SDF produced a greater increase in salivary pH at one week than NaF varnish. Given its high parental acceptance and non-invasive nature, SDF may be a useful option for managing early childhood caries, particularly in young children who have difficulty cooperating with conventional dental treatment.
Materials and methods: In this randomized, single-blind clinical trial, 60 children aged 6–10 years with active non-cavitated or superficially cavitated carious lesions (ICDAS codes 1-3) were randomly assigned to receive either 38% SDF or 5% NaF varnish. Unstimulated salivary pH was measured at baseline and one week after treatment. Caries arrest was clinically evaluated after three months. Parental acceptance of SDF was assessed using a Likert-scale questionnaire. Statistical analyses included paired and independent t-tests and chi-square tests.
Results: Salivary pH increased significantly in both groups one week after treatment (P< 0.001), with a significantly greater increase in the SDF group. Caries arrest was observed in 96.7% of lesions in the SDF group and 90.0% in the NaF group, with no statistically significant difference between groups (P= 0.301). All parents rated SDF application as painless and easy to administer, and reported acceptable taste and discoloration.
Conclusion: Both SDF and NaF varnish were effective in arresting caries in primary teeth. SDF produced a greater increase in salivary pH at one week than NaF varnish. Given its high parental acceptance and non-invasive nature, SDF may be a useful option for managing early childhood caries, particularly in young children who have difficulty cooperating with conventional dental treatment.
(Clinical Trials Registry Number: IRCT20241019063428N1)
Keywords: silver diamine fluoride, sodium fluoride, cariostatic agents, dental caries, early childhood caries
Type of Study: Research(Original) |
Subject:
Dentistry
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