Volume 10, Issue 26 (Mar 2000)
J Mazandaran Univ Med Sci 2000, 10(26): 1-8 |
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Kosarian M, Valaee N, Mahdyanee A. Do the Desferal Thalassemic Patients have Zinc Deficiency receiver . J Mazandaran Univ Med Sci 2000; 10 (26) :1-8
URL: http://jmums.mazums.ac.ir/article-1-282-en.html
URL: http://jmums.mazums.ac.ir/article-1-282-en.html
Abstract: (16137 Views)
Background and purpose: The zinc deficiency has a known side effects and zinc deficiency in Ïron is a known phenomenon. Thalassemic patients under treatment with Ïron shlator i-e Dispheral, discharge some amount of zinc. Hence zinc deficiency is a matter of thought.
Ïn order to determine the relation between dispheral usage and zinc deficiency this study was conducted on the thalassemic patients referring to sari BoÂli Sina Hospital in 1377.
Materials and methods: This was a cohort study. The test group comprised of confirmed thalassemia major cases under the treatment of blood transfusion and the control group comprised of sisters and brothers of these patients. 5 ml blood was drawn from the fasting patients, and the 24 hours urine was collected. Zinc was measured by RÜNDÔX kit with the help of atomic absorption instrument and the urine creatinine was measured by RÂ-1000 auto analyser. Signed rank test was used for the comparison of the age between these two groups due to differences in the obtained data.
Results: 32 cases under study were in 16 similar pairs. The rate of serum zinc in the control group was 98 ± 17 microgram and in dl case group was 112.7 ± 23 micro gram/dl (P<0.001). The serum zinc level compairing with the normal range of the used kit was normal in micro gr/dl both groups. The 24hrs. urine zinc level was 96 ± 12 and 120 ± 66 micro gr/dl in control and case group respectively (P<0.05). The urine creatinine level (mg/kg) was the same in the both groups.
Çonclusion: Desferal user thalassemia major patients excrete more zinc than the control group but this phenomenon would not lead to serum zinc deficiency. Probably due to frequent blood transfusion these patients receive significant amount of zinc. More study on the effects and the role of frequent blood transfusion on the serum and urine zinc level is recommended.
Materials and methods: This was a cohort study. The test group comprised of confirmed thalassemia major cases under the treatment of blood transfusion and the control group comprised of sisters and brothers of these patients. 5 ml blood was drawn from the fasting patients, and the 24 hours urine was collected. Zinc was measured by RÜNDÔX kit with the help of atomic absorption instrument and the urine creatinine was measured by RÂ-1000 auto analyser. Signed rank test was used for the comparison of the age between these two groups due to differences in the obtained data.
Results: 32 cases under study were in 16 similar pairs. The rate of serum zinc in the control group was 98 ± 17 microgram and in dl case group was 112.7 ± 23 micro gram/dl (P<0.001). The serum zinc level compairing with the normal range of the used kit was normal in micro gr/dl both groups. The 24hrs. urine zinc level was 96 ± 12 and 120 ± 66 micro gr/dl in control and case group respectively (P<0.05). The urine creatinine level (mg/kg) was the same in the both groups.
Çonclusion: Desferal user thalassemia major patients excrete more zinc than the control group but this phenomenon would not lead to serum zinc deficiency. Probably due to frequent blood transfusion these patients receive significant amount of zinc. More study on the effects and the role of frequent blood transfusion on the serum and urine zinc level is recommended.
Type of Study: Research(Original) |
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