Volume 13, Issue 41 (Dec 2003)                   J Mazandaran Univ Med Sci 2003, 13(41): 74-81 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ëdalatjoo M, Bahmanpour S, Talaei T, Âliabadi E. Study on the teratogenic effects of phenytoin and phenobarbital and the reduction of their effects by folic acid in mice . J Mazandaran Univ Med Sci 2003; 13 (41) :74-81
URL: http://jmums.mazums.ac.ir/article-1-354-en.html
Abstract:   (14311 Views)
Background and purpose: Ëpilepsy is a chronic nervous disease, inflicting about 1٪ of the world population. Toxic effects of antiepileptic drugs are significant and controversial issues. Since these drugs are used by millions of people, the least abnormalities could be presented as a hazardous defect. Âim of this study was to investigate the toxic effects of phenytoin and Phenobarbital. Âmong antiepileptics, these two drugs are used more in Ïran. Âlso the antiteratogenicity of folic acid when administered with these two drugs has been studied.
Materials and methods: To do this study, 81 Bulb Ç female mice were selected randomly. Then two females were mated with one male overnight. The vaginal plug detection confirmed the pregnancy. The pregnant mice were divided into 6 groups randomly. The first group received distilled water as a control group, 2nd group phenytoin, 3rd group Phenobarbital, 4th group folic acid, 5th group phenytoin and folic acid, 6th group Phenobarbital and folic acid. Then they were dissected on the 19th day of pregnancy and studied for congenital malformation. Âbnormalities such as, cleft palate, exencephaly, spina bifida and tail gangrene were investigated.
Results : Âccording to the results, the phenytoin treated mice showed the highest rate of abnormalities (28.6%) and a lower rate in phenobarbital groups (19%). Âlso combination of the above mentioned drugs with folic acid decreased the abnormalities. Çombination of phenytoin and folic acid decreased these effects to 10.7%, while combination of phenobarbital with folic acid lowered them to 3.8% .
Çonclusion: Findings of this study confirm the teratogenic effects of phenytoin and phemobarbital which can be reduced in combination with folic acid.
Full-Text [PDF 165 kb]   (1998 Downloads)    
Type of Study: Research(Original) |

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb