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Background and purpose: H. pylori infection in the stomach is the first major cause of gastritis and peptic ulcer disease and gastric adenocarcinoma and lymphoma (MALT). Evaluation of the infection eradication is important. H. pylori infection is associated with gastric glands dysfunction such as increased serum gastrin and increased secretion of Pepsinogen. In recent years, the measurement of serum gastrin and pepsinogen have been considered in the evaluation of Helicobacter pylori eradication. Material and Methods: In a prospective cohort study, we evaluated the changes of serum gastrin in H. pylori-positive patients after eradication therapy, and we assessed the correlation of serum gastrin with successful eradication therapy. Results: Gastrin serum levels significantly decreased after successful eradication in comparison with unsuccessful eradication. 31% of the reduction of gastrin level after 8 weeks of treatment had 92.5% sensitivity and 100% specificity for successful eradication. Conclusion: According to the findings of this study and other previous studies, changes in the gastrin serum levels, can be a reliable indicator of successful eradication of H-pylori infection. Although our study showed that changes in gastrin levels have a sufficient sensitivity and specificity of treatment, but in our study, some factors including atrophic gastritis and age affecting gastrin serum levels were not considered.

Keywords: H.pylori, gastrin, successful eradication

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