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Background and purpose: One of the major complications in diabetes mellitus is lower extremity amputation. Amputation can affect different aspect of patient’s life and cause various morbidities. The purpose of this study was to observe the effect of amputation on quality of life and determining the frequency and causes of mortality in these patients. Material and Methods: This study was performed in Rasool Hospital in Tehran from 2011 to 2013. The study population included 121 known cases type II diabetic patients with amputation of lower extremity in different levels who were followed for four years. SF-12 questionnaire has been used for quality of life and causes of mortality in this period were recorded. Data was analyzed using Chi square and T test in SPSS. Values less than 0.05 were considered significant. Results: Four years mortality of diabetic patients with amputation has been determined about 36%. The most common causes of mortality were cardiovascular diseases (63.4%), renal diseases (14.6%), cerebrovascular accidents (12.2%), and infection (9.8%). There was no correlation between rate of mortality and numbers and site of amputations but direct correlation was found with daily insulin dose. Quality of life scores in both physical and mental components were lower in dead patients compared with those of the alive patients (P= 0.03 and 0.009, respectively) but considering the numbers of amputations, only different in mental components were statistically significant (P=0.00). Conclusion: Diabetic patients must be carefully followed for different complications, especially mental components. So, paying more attention to this component and adding psychiatric and psychological consultations in routine follow ups could be highly beneficial.

Keywords: Diabetes mellitus, quality of life, diabetic mortality

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