Hashemi S M J, Janbabai G, Hashemi Soteh S M B, Shekarriz R, Mahdavi M R, Ghaemian A et al . Investigating Factor V Leiden and Prothrombin G20210A Gene Mutation in Relation with Acute Myocardial Infarction. J Mazandaran Univ Med Sci 2014; 24 (117) :21-28
URL:
http://jmums.mazums.ac.ir/article-1-4455-en.html
Abstract: (7983 Views)
Background and purpose: Beside the environmental determinants there are major genetic
factors that could cause Myocardial Infarction (MI). The aim of this study was to clarify the relationship
between factor V Leiden and prothrombin G20210A with acute MI in patients younger than 50 years of
age.
Materials and methods: In this case-control study we recruited 101 MI patients and 101 healthy
individuals in Fatemeh Zahra Hospital, affiliated to Mazandaran University of Medical Sciences. Demographic
information and risk factors including age, past history of MI, diabetes mellitus, hypertension, dyslipidemia,
and smoking were recorded. Genes of factor V Leiden and prothrombin G20210A were analyzed using PCRRFLP
method.
Results: Among all subjects, 191 (94.55%) had no factor V Leiden gene, 10 (4.95 %) were
heterozygous, and one (0.49%) was homozygous. In case group, and control group there were seven
(6.9%) and three (2.97%) heterozygous for factor V Leiden, respectively (P= 0.27). There was no
mutation of prothrombin G20210A gene in 197 (97.5%) individuals and only five (2.5%) were
heterozygous. There was no statistically significant difference between the two groups (P= 0.17).
Conclusion: The prevalence of factor V Leiden and prothrombin G20210A gene mutation, in
patients was not significantly different from that of the normal individuals. However, further studies are
recommended in this age group to investigate these factors.
Type of Study:
Research(Original) |
Subject:
genetic