Volume 24, Issue 121 (2-2015)                   J Mazandaran Univ Med Sci 2015, 24(121): 414-430 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amjadi O, Abedini M, Rafiei A, Safaii S, Ajami A, Hosseinian A. Interferons in Autoimmune Diseases: Friend or Foe. J Mazandaran Univ Med Sci 2015; 24 (121) :414-430
URL: http://jmums.mazums.ac.ir/article-1-5196-en.html
Abstract:   (8937 Views)
Interferons (IFNs) are pleotropic cytokines with strong anti-viral and immunomodulatory properties. Their function is dependent to signaling pathway upon binding to IFN receptor. Both pro- and anti-inflammatory effects are seen in interferons-related immune responses. While, interferons are in direct correlation with autoantibodies production during autoimmunity, they have protective effects. This paradoxical role of interferons may impose on immunopathogenesis of autoimmune diseases and selecting appropriate medical strategies. Here, we will review the role of interferons in autoimmune diseases such as giant cell arteritis and describe a general overview on their dual role in autoimmune diseases including, systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and scleroderma.
Full-Text [PDF 258 kb]   (7094 Downloads)    
Type of Study: Review | Subject: Immunology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb