Volume 19, Issue 69 (Mar 2009)
J Mazandaran Univ Med Sci 2009, 19(69): 79-87 |
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Shiari R, Nasehi M, Farivar S, Hatamian B. The survey of anti-inflammatory effect of bisphosphonates. J Mazandaran Univ Med Sci 2009; 19 (69) :79-87
URL: http://jmums.mazums.ac.ir/article-1-542-en.html
URL: http://jmums.mazums.ac.ir/article-1-542-en.html
Abstract: (12350 Views)
Bisphosphonates are currently used in metabolic disorder of bone however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in-vivo. Bisphosphonates were divided in two classes regarding the structure and mechanism, including amino and non-amino bisphosphonates. The effect of bisphosphonates on cytokine related to in-vitro was complex and related to type and dose of bisphosphonates, examination of cell type and cell culture evaluation system. However, amino bisphosphonates activated inflammatory cytokine regarding to in-vivo and chronic usage of this agent, can stop the production of these cytokines. Present study surveyed the anti -inflammatory and immune modulatory effect of bisphosphonates and clinical trial, along with recent knowledge about potential mechanism of this component.
Type of Study: Research(Original) |
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