Volume 11, Issue 33 (Dec 2001)
J Mazandaran Univ Med Sci 2001, 11(33): 57-62 |
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Saffar M, Kosaryan M, Jafari M. Immunogenicity of low dose intradermal hepatitis B vaccine. J Mazandaran Univ Med Sci 2001; 11 (33) :57-62
URL: http://jmums.mazums.ac.ir/article-1-64-en.html
URL: http://jmums.mazums.ac.ir/article-1-64-en.html
Abstract: (16936 Views)
Background and purpose : Hepatitis B viral infection (NBÏ) and its sequelae are a major worldwide health problem. The most effective way to contral and prevent HBÏ is univerral immunization with hepatitis B vaccine (HBÏ). But the most limitation of it is inadequate resource. The aim of this study is to evaluate the immunogenitity of low dose immtradermal (ÏD) HBV, according to routine intramuscular (ÏM) route.
Materials and Methods : Â clinical trial study on 113 fullterm neonates from HBSÂg. Negative mothers in two case and control groups was conduted. Çase group received 2 μg ÏD HBV, and contral group recived 10 μg ÏM HBV at 0, 105 and 6 moths of age. 4 wks after last dose serum Ânti HBSÂg Ântibody titer was quantitied by ËLÏSÂ.
Results : The results showed 19 out of 23 (82.6%) in case and 27 out of 28 (96.4%) in control group had complete response (10 ÏÜ/ml ≤). The difference by X2 was not significant. The mean geometelic titer (GMT) in case was 447 ± 336 and in contral 658 ± 378, the difference by X2 was significant,
Çonclusion : Âccording to obtained data, low dose ÏD HBV can induce comparable immunologic response. But funther studies with larger sample size and detection of durability of protection isneeded.
Materials and Methods : Â clinical trial study on 113 fullterm neonates from HBSÂg. Negative mothers in two case and control groups was conduted. Çase group received 2 μg ÏD HBV, and contral group recived 10 μg ÏM HBV at 0, 105 and 6 moths of age. 4 wks after last dose serum Ânti HBSÂg Ântibody titer was quantitied by ËLÏSÂ.
Results : The results showed 19 out of 23 (82.6%) in case and 27 out of 28 (96.4%) in control group had complete response (10 ÏÜ/ml ≤). The difference by X2 was not significant. The mean geometelic titer (GMT) in case was 447 ± 336 and in contral 658 ± 378, the difference by X2 was significant,
Çonclusion : Âccording to obtained data, low dose ÏD HBV can induce comparable immunologic response. But funther studies with larger sample size and detection of durability of protection isneeded.
Type of Study: Research(Original) |
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