Background and purpose: Grapes are abundantly found and consumed by people all over the world. Holy Quran has more than a thousand verses about scientific facts and some of them are regarded as the scientific miracles of Quran. Holy Quran has mentioned grape 11 times. The holy book advises human to use both vegetables and animal source foods. This study aimed to review medicinal and nutritional properties of grapes from the Quran’s point of view and Iranian Islamic medicine.

Materials and methods In this review study, some scientific databases such as Scopus, Google scholar, PubMed, Science Direct, and Ovid were used. Also, Holy Quran, Islamic narrations and hadith, books about traditional medicine and medicinal plants were studied. The findings were restricted to works published during 1994 to 2014. The keywords included medicinal plant, anticancer effect, Holy Quran, and grape. Finally, the data was categorized.

Conclusion: Holy Quran mentioned consuming grapes several times. Also, Imams emphasized using this fruit. Researches have shown high antioxidant activity of grape in treatment of many diseases including alzheimer, parkinson, asthma and different cancers. The current study showed the scientific miracles of Quran about grapes and their known and unknown nutritional values.