Pregabalin is used as a new drug in relieving neuropathic pain but it could have some side effects such as dizziness, drowsiness and peripheral edema. Other side effects are rarely reported. We report a patient who developed urinary incontinence following a single dose of Pregabalin. A 72 year old woman was diagnosed with depression and received treatment from two years ago but complained of scattered body pains. After further investigations she was diagnosed with fibromyalgia and was given Pregabalin75 mg daily. After a single dose of Pregabalin the following symptoms were presented: tearing, impaired concentration, and urinary incontinence. The symptoms were resolved within 4-5 hr and Pregabalin was stopped the next day.  According to the Naranjo probability scale these symptoms were probably due to Pregabalin. Therefore, it should be prescribed cautiously in older adults.