Background and purpose: Fatigue is a common symptom in patients undergoing hemodialysis. Reflexology is a nursing intervention that could reduce fatigue. This study aimed at determining the effects of foot reflexology on fatigue in patients undergoing hemodialysis.

Materials and methods: A clinical trial with before and after design was conducted in hemodialysis patients attending Imam-Ali and Iran-mehr clinic in Bojnurd, 2013. Using randomized sampling 78 patients were allocated into three groups: intervention, placebo, and control group. The patients in intervention group received foot reflexology, and simple foot reflexology without pressing certain parts of the foot was done in placebo group. The patients in control group received only routine care. Piper Fatigue Scale was used to measure fatigue level before and after the intervention. Data was analyzed using descriptive statistics, one-way ANOVA and Paired t-test.

Results: The results showed a significant difference between fatigue scores in intervention and control groups before and after the intervention (P<0.001). After the foot reflexology, the fatigue score in intervention group reduced to 3.8±1.27 (vs. 4.34±1.35 before the intervention), while the fatigue score in control group increased to 5.19±0.87 (vs. 4.91±1.04 before the intervention) (P<0.05). The placebo group showed no significant difference before and after the intervention (P=0.9).

Conclusion: Reflexology can be used as a nursing intervention in reducing fatigue among patients undergoing hemodialysis.