Showing 2 results for Arab Firozjae
Atefeh Arab Firozjae, Mohammad Azadbakht, Emran Habibi,
Volume 31, Issue 205 (2-2022)
Abstract
Background and purpose: Mushrooms are natural sources that have antitumoral effects, immunomodulatory and anti-oxidant effects. One of the fungus which remained intact is Daedaleopsis tricolor that belongs to the family of Polyporaceae. There are limited phytochemical investigations on other species of this genus, so, we aimed at performing a phytochemical analysis of this fungus.
Materials and methods: Fungal components were extracted by hexane using maceration method. Then, the extract was concentrated under reduced pressure using a rotary evaporator. The concentration extract was subjected to silica gel column chromatography through mobile phases consisting of hexane: ethyl acetate. Three fractions of hexane purified extract were called F3, F2, and F1. They were analyzed by 1H-NMR and 13C-NMR Spectroscopy and DEPT 90 and DEPT 135 experiments.
Results: After analysis and receiving the spectrum results and comparing them with other studies, we identified ergosterol derived compounds, ergosterol peroxide, ergosta-7, 22-dien-3β-ol, and linoleic acid.
Conclusion: The three compounds, including ergosterol peroxide, ergosta-7, 22-dien-3β-ol, and linoleic acid were reported for the first time in this fungus.
Seyed Hamzeh Hosseini, Hossein Khadem Haghighian, Zahra Yari Sarokolae, Atefeh Arab Firozjae, Sara Bayat, Reza Eshaghi Gorji, Majid Saeedi, Gholamreza Houshmand,
Volume 35, Issue 244 (5-2025)
Abstract
Background and purpose: Changes in Brain-Derived Neurotrophic Factor (BDNF) levels are associated with psychiatric disorders, including depression. Research has demonstrated that patients suffering from depression exhibit reduced BDNF levels, and antidepressant treatments have been shown to increase these levels. Gallic acid, a natural compound known for its antioxidant and neurotrophic properties, shows significant potential for enhancing BDNF levels and alleviating depressive symptoms. This study aims to investigate the effect of gallic acid supplementation on serum BDNF levels in patients diagnosed with depression.
Materials and methods: This study was conducted using serum samples obtained from our previous research involving 30 patients diagnosed with major depressive disorder who visited Shahid Zareh Hospital in Sari. The patients were randomly divided into two groups: an intervention group and a placebo group. Individuals in the intervention group received 200 mg of gallic acid daily in capsule form. Blood samples (10 cc) were collected from each participant at both the start and the end of the study. Following serum separation, the levels of BDNF in the plasma samples were measured using a specific ELISA kit.
Results: After the intervention, the findings showed a significant difference between the plasma BDNF levels of the research groups. The plasma BDNF levels in the intervention group increased significantly compared to the placebo group.
Conclusion: According to the results, gallic acid supplementation increases the level of BDNF, and this supplement may be used in conjunction with existing antidepressants to reduce the side effects of current drugs.
(Clinical Trials Registry Number: IRCT20141025019669N17
