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The best example of irritant induced occupational asthma is reactive airways dysfunction syndrome (RADS) which is usually unregarded. We present a 29-year-old security guard from an Iranian car manufacturing company who was exposed to heavy smoke during a fire in work place in five years ago. He was referred because of his persistent asthma like symptoms after that accident to determin the accosiation between profession and the symptoms. He fulfilled criteria for RADS according to Brook’s criteria, therefore his asthma was reported as work related.