David Darvishnia, Narges Najafi, Alireza Davoudi, Atieh Jafari, Maryam Mirzakhani,
Volume 32, Issue 210 (7-2022)
Abstract
Background and purpose: The term nosocomial infection refers to any type of infection that does not exist at the time of hospital admission and occurs within 48-72 hours after admission or up to 3 days to 6 weeks after discharge, or 30 days after surgery. Nosocomial infections can cause side effects, mortality and reduce quality of life in patients. So, so we decided to study the clinical, laboratory, and microbiological characteristics of patients with heart disease and nosocomial infections in Sari Fatemeh Zahra Hospital.
Materials and methods: In this descriptive study, 22811 people were studied. Information were recorded, signs of infection in patients were reviewed and in case of symptoms, patients were further examined. Data analysis was performed in SPSS ver.18.
Results: In this study, 1.4% of patients developed nosocomial infections. The mean age of patients was 64.5±12.5 years and the majority of patients were males (53.3%). The most common underlying diseases were hypertension, diabetes, and hyperlipidemia. The most common type of nosocomial infection was respiratory infection (47.8%) and the most common bacteria found in culture medium was Escherichia coli. Acinetobacter was resistant to all antibiotics tested except colistin which was susceptible in 80% of cases and resistant in 20%.
Conclusion: Control and prevention of nosocomial infections is of particular importance, especially in patients admitted to intensive care units after heart surgery.
Atieh Makhlough, Narges Mirzaei Ilali, David Darvishnia, Hadi Darvishi-Khezri, Ali Sharifipour, Hossein Mehravaran, Masoud Aliyali, Sepideh Safanavaiee, Siavash Abedi, Babak Eslami,
Volume 33, Issue 1 (11-2023)
Abstract
Background and purpose: Novel coronavirus (COVID-19) can cause acute kidney injury (AKI), and underlying kidney diseases worsen the prognosis of COVID-19 patients.
Materials and methods: This observational study examined the clinical and laboratory outcomes of patients with COVID-19 and assessed the major risk factors for death and intensive care unit (ICU) hospitalization in COVID-19 patients. The sample consisted of 296 COVID-19 patients with or without underlying kidney diseases. In total, 37 patients died (mean age: 66.6 ± 17.6).
Results: Most patients who passed away initially suffered from shortness of breath (37.8%), cough (21.6%), old age, insulin use, central nervous system (CNS) disease, septic shock, hypoalbuminemia (P<0.0001), and high international normalized ratio (P<0.0001). Median time to death was higher in patients hospitalized in the ICU than in those without chronic kidney disease (OR=3.08; P=0.006). The use of azithromycin and ceftriaxone was lower than the use of Recigen and meropenem in deceased people (P<0.0001).
Conclusion: The risk of mortality and ICU hospitalization was higher in patients with CKD than in those without CKD. The results revealed the therapeutic effects of azithromycin and ceftriaxone and the side effects of Recigen and meropenem in deceased COVID-19 patients. In addition, low albumin level, high INR, neutrophil count, white blood cell (WBC) significantly increased the risk of death in these patients.
