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Showing 3 results for Diabetic Foot

Adele Bahar, Majid Saeedi, Zahra Kashi, Ozra Akha, Khadijeh Rabiei, Mehdi Davoodi,
Volume 25, Issue 128 (9-2015)
Abstract

Abstract Background and purpose: Diabetic foot ulcers are one of the major causes of morbidity and mortality in diabetic patients. For centuries Aleo vera has been used in treatment of diabetic foot ulcers. In this study, a mixture of honey and Aloe vera was used for diabetic foot ulcer healing. Materials and methods: In a double-blind clinical trial, patients with nonischemic, noninfected diabetic foot ulcers (attending Imam Khomeini Hospital Diabetes Center, Sari, Iran) were divided into two groups, a treatment group (n= 24) and a placebo group (n=15). To compare the effect of the mixture t-test and qui square were applied. Results: A total of 39 patients (19 males and 20 females) with diabetic foot ulcers were enrolled. Mean age of the patients, mean body mass index, and mean duration of diabetes were 56.3 ±10.2, 31.2 ± 4.2, 16.2 ± 6.6, respectively which were not significantly different between the two groups. Wound size was determined using a ruler that showed no significant difference between the two groups (P=0.36). Debridement, offloading and washing were done for all participants. Combined gel of Aleo vera and honey was used for treatment group. Wound healing was seen in 21 (95.5%) patients in treatment group and in 11 (78.6%) patients in placebo group. Conclusion: In small, non-infected, non-ischemic ulcers the effect of honey and Aloe vera gel was the same as that of the placebo. Offloading, debridement and washing with normal saline have similar effect to the mixture in healing diabetic foot ulcers.
Ahmad Alikhani, Mohammadzaman Moradi, Shayan Alikhani,
Volume 25, Issue 129 (10-2015)
Abstract

Background and purpose: Diabetic foot infections are the most common problems that result in disability and hospitalization of diabetic patients. Preventive measures can decrease the incidence of diabetes and its complications thereby, reducing the economic cost of associated health services. The aim of this study was to evaluate the prevalence of predisposing factors in diabetic foot ulcer infection and the frequency of different clinical outcomes and their relationships with predisposing factors. Materials and methods: This analytical study was done in 200 hospitalized patients with diabetic foot infection in Sari teaching hospitals, 2013-14. Patients were evaluated for symptoms and signs of ulcer infection, neuropathy and vasculopathy. Also, demographic characteristics of all participants were recorded. Data was analysed in SPSS V.16. Results: The patients were 54% male and 46% female (mean age 58.3+10.2 years). Amputation was performed in 20.5% of the patients of whom 75% were male. The most common location of diabetic foot ulcer was the hallux and ankle was the least infected location. All the cultures were positive and the most prevalent pathogens were staphylococcus aureus (28%) and Pseudomonas aeruginosa (14.5%).The results showed that previous history of ulcers and amputation and osteomyelitic changes in foot X-ray could predict risk of amputation. Conclusion: Diabetes is so prevalent in Iran, therefore, it is important to reduce the incidence of diabetes complications by providing appropriate training to the patients, their families and healthcare staff.
Mohammad Reza Amini, Maryam Aalaa, Mahnaz Sanjari, Neda Mehrdad, Mohammad Reza Mohajeri Tehrani, Hanieh-Sadat Ejtahed,
Volume 30, Issue 193 (1-2021)
Abstract

 Diabetic foot ulcer (DFU) is one of the common reasons for non-traumatic amputation of the lower limbs, which requires proper diagnosis, proper collection of specimens, careful selection of antibiotics, treatment of infection based on the disease condition, quick decision about whether or not surgery is necessary and other types of wound care. Probiotics are suggested as non-pathogenic microorganisms due to antibiotic resistance in the treatment of DFU. The effects of probiotics on immune function, skin diseases, and diabetes have been studied and recent evidence suggests their effect on DFU through controlling hyperglycemia, improving immune function, and modulating the microbiota as possible mechanisms. In this review article, we discuss the role of probiotics in healing chronic infected wounds of the diabetic foot from several perspectives including the role of microbiota in glycemic control, the effect of probiotics on the immune system, inflammatory markers, wound healing acceleration, and infection control. Topical application and oral intake of probiotics, especially when used as adjunctive therapies with antibiotics, seems to facilitate the healing process of infected diabetic foot ulcers.

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