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The familial spastic paraplegia (FSP) is a heterogeneous group of motor neuron disorders characterized by slow progressive weakness and spasticity of lower limbs. The disorder can appear at any age, but it usually occurs in childhood or early adult life. The genetic pattern of this disease is mainly autosomal dominant trait, but occasionally as an autosomal recessive trait, and very rarely as an X-linked recessive disease. The prevalence of this disease ranges from 2.0 to 4.3 per 100000. In this study, there were 5 patients in a family and 3 in another family who had weakness and spasticity of lower limbs in the first decade of their life. In physical examination, there were normal sensation, ankles spasticity, extensor plantar reflexes, deep tendon reflexes 4.2, tip toe walking, contracture of knees and ankles. Genetic pattern of disease was these patients is autosomal dominant trait.

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while vaccination against SARS‐CoV‐2 could stop the pandemic of COVID19, there are still concerns about the vaccine‐related side effects.One of the neurological adverse effects following administration of COVID vaccines  is motor neuron disease. In this case we report a unique case of motor neuron disease post the second dose of Sinopharm vaccine is presented.A 43 years old man with no evidence of prior SARS COV2 infection presented with progressive muscular weakness after receiving the second dose of Sinopharm covid-19 vaccine.
Upon physical examination, laboratory data, Electromyogram and Nerve Conduction Study (EMG-NCS) and also muscle biopsy suggested the diagnosis of Covid-19 associated motor neuron disease. The patient was treated with Riluzole and Edaravone to delay the progression rate. This case described a possible link between Covid-19 Sinopharm vaccine and motor neuron disease. However further data are required to confirm such an association.