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Background and purpouse : Thalasemia major is one the most prevalent congenital anemia. These patients recieved much rate of iron, due to frequent blood transfusion. Indocrine disorders are prevalent due to replacement of iron in indocrinal gland system, example can be of hypogonadism. In this study the delay of puberty in thalasemic patients of Gorgan city and its relevance to the rate of ferritin was evaluated.
Materials and Methods : This was a case control study conducted on 110 thalasemia major patients in the age group of 8-18 referred to Taleghani pediatric Hospital to receive blood. In 62 control group patients (31 females and 31 males) electeropheresis was done on their blood. The talassemic patients were divided into two groups on the basis of ferritin level. Those with ferritin level less than 1500 mg/dl (31 females , 18 males) In all the groups the stages of sexual puberty was calculated on the basis of Marshal-Tanner table with the 1-5 scale. For better studying of the groups of one and two, they were divided in subgroups of 8- 11, 12- 14, 14- 18 years of age.
Results : There was no significant difference of puberty in the control and case group of age 8- 11 years old. But there was a significant difference (P<0.01) in the case and control group of 12- 14 years old. And in the age group of 14- 18 result was different, that means, none of female case group had complete puberty while in the female control group all had complete puberty. In case of males, onset of puberty was less as compaire to control group and none had complete puberty.
Coclusion : This study showed that if the ferritin level in talassemic patient is not under control, it would lead to delayed sexual puberty in both sexes

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Background and purpose: Determination of hight and weight and processes of puberty in students could be one of the best indices for evaluation of nutritional and growth status of the population of a society. Taking in to account that the information available at present is from western societies, we decided to perform the same in our society.
Materials and methods: Ôn the basis of a trial study with cartain sample size, random sampling of 1266 boy students in the age group of 7-17 in sari township were done. The materials used for the research were strap scale, ruler, spring weighing device and orchiometer for measurment of testis.
Results: Maximum increase in hight and weight was observed at the age of 13 years. Ïncrease in hight and weight continued till 14 years of age and then the rate slowed down. The first sign of puperty was the growth of pubic hair.
Çonclusion: Çonsidering the difference between the percentage of hight and weight with the available standard percentage, preparation of a new standard percetage for our society is recommended.

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Background and purpose: Planning for adolescent’s prepation to face with puberty requi careful formation of their behavior and educational needs in onder to provideeducational information. This study was undertaken to determine KÂP girls Secondary students about puberty health in Mazandaran State 2003.
Materials and methods : This research is an analytical study on 1708 Mazandaran adolescents KÂP for education. Sampling was done by sequentioal method. Data collated using a questioner containing demographic awareness. Âttitude and peractic questions about puberty health. Then based on results educational needs. Were detaming. Data was analyzed using spss program and X2, variance analysis, regression.
Result : Mean age and mean age of menarche were 13/33 and 12/3 year respectively educational status of most parents were low(35%), %5.8 of girls knew the meaning of puberty and puberty health awareness(33.4%) was weak. The rate of exercises, bath andnutrition during menses due low knowledge were low (p<0001). Ïnstead of positive attitude to menstruation (73.3%) emotional practice about that was weak (67.8%). Mothers were the first source of information in 62% of girls which explaies thien low level of information (p<0001). Sgnificant relationship was between awareness and health practice (p<0.0001).
Çonclusion: Despite of willingness of most girls to more about puberty their health information and practice about puberty was low. The other important point is that information should not be limited to knowledge of puberty and menses mechanism, but deeper standing of physical and psychological changes and theirs connection with sex, fertility and marriage health is required.

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Background and purpose: Measurement of height and weight of children and adolescents are important sources of information and the best index for evaluation of their growth and nutritional and health status of society. This study performed to evaluate weight, height and pubertal stage of girls in sari.
Materials and methods: This cross – sectional study was performed on 1320 6-18 years old school girls in elementary guidance and high school of Sari. Their height, weight and pubertal stage were evaluated and recorded by educated personas . Also Body Mass Index was calculated and recorded. Then Z score (SDS) of weight, height and the Body Mass Index studied people was compared by using calculated standard curve and findings in NCHS curve and findings of 1997 in Sari. For analyzing data, descriptive statistics, Mean±SD, Frequency and percent were used.
Results: By using NCHS curve 1256 persons ( 95. 2 % ) from total persons that were studied , had normal height ( 5 – 95 percentile ) and the weight of 1254 persons ( 95 % ) were in 5 - 95 percentile . 2/5 centemers increasing in height and 2.5 Kg increasing in weight were seen in comparison to 1997 study .BMI of persons in all age groups ( expect 17 year old with ± 0.05 SD )were over than 50 percentile and mean age of beginning of menarche was 11.4 ± 1.1 .
Conclusion: Our study in Sari shows the improvement in growth index in comparison to 1997 study which become near to standard curve in developed country.

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Background and purpose: The precocious puberty in girls can have some adverse effects such as growth stoppage and subsequent short stature in comparison with predicted final adult height. GnRH agonists are now considered the treatment of choice for CPP. One of the side effects of these drugs is increased appetite and consequent obesity. During puberty a progressive reduction in the level of ghrelin has been reported. This study was aimed to assess the obesity and its relationship with ghrelin in girls with true precocious puberty treated with GnRH agonists. Materials and methods: A sample of 20 consecutive girls with true precocious puberty was selected for this prospective observational study. They received 3.75 mg intramuscular GnRH every four weeks. Height, weight, body mass index, waist circumference, Tanner stage, body fat and serum ghrelin, were measured in the time of enterance to study and during follow up visits. The follow-up visits were carried out after 6 and 12 months. Results: Mean age of the studied 19 child was 87.5 ± 10.1. Height and weight increased significantly after 6 and 12 months, P-value<0.01. The ghrelin level and body fat percentage demonstrated no significant change during the 12 months follow-up, P-value>0.05. There were not any significant relationships between neither ghrelin and BMI nor ghrelin and body fat percentage, P-value>0.1. Conclusion: It seems that treatment with GnRHa is effective. More importantly patients with increased BMI may need appropriate dietary consultation to accomplish their weight control during the course of the treatment.

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Background and purpose: Puberty is one of the most critical stages in the life of every girl in adolescence. The purpose of this study was to determine the impact of peer education on girls' knowledge and practice about puberty.
Materials and methods: In this semi-experimental study, 10 eighth-grade classes were selected from ten high schools in Shahroud, Iran 2018, using multi-stage sampling. Random assignment of schools to two groups of control and intervention was done. A total of 217 students enrolled in this research. Demographic characteristics were recorded and students completed a researcher-made questionnaire on puberty before, immediately after, and one month after the intervention. The intervention group received peer education on puberty by trained individuals for one month. Data were analyzed using descriptive statistics. The alpha level of 0.05 was considered significant.
Results: There were no significant differences between the two groups in the mean scores for knowledge and practice before the intervention (P= 0.17). The mean scores of knowledge and practice in intervention group were 28.18±3.85 and 121.59±10.32 immediately after the intervention, and 31.91±3.69 and 130.37±8.07 one month after the intervention, respectively which were significantly higher than those of the control group (P= 0.001).
Conclusion: Collaborative nature of peer education makes it an appropriate choice for educating puberty issues to adolescents.
 
(Clinical Trials Registry Number: IRCT20180209038675N1)