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Showing 2 results for Engraftment

Farzaneh Tavakoli, Elham Roshandel, Hossein Bonakchi, Abbas Hajifathali, Sayeh Parkhideh,
Volume 31, Issue 199 (8-2021)
Abstract

 Background and purpose: Several studies investigated the role of C-reactive protein (CRP) during transplantation and inflammation, and clinical outcomes after stem cell transplantation. In this study, we examined the relationship between the earliest CRP level on admission day, and the first outcome after transplantation, myeloid and platelet engraftment, and the length of hospitalization in patients with Autologous hematopoietic stem cell transplantation (Auto-HSCT).
Materials and methods: In this retrospective study, using clinical records from 2014-2020, information including patients’ demographic characteristics, CRP levels on admission day, white blood cell, and platelet counts were investigated. Engraftment day and duration of hospitalization were also recorded. To analyze the data, Cox regression, score process plot, Kolmogorov-type supremum test, and linear regression were performed.
Results: Results did not show a significant relationship between CRP level on first day of hospitalization, the day of myeloid and platelet engraftment, and duration of hospitalization (P values= 0.91, 0.68, 0.39 respectively).
Conclusion: Future studies, assessing changes in CRP levels, along with the impact of other inflammatory factors during conditioning chemotherapy or the day of stem cell injection, might improve our understanding of lymphoma and multiple myeloma treatment and management.
Mahshid Mehdizadeh, Hossein Bonakchi, Farzaneh Tavakoli, Maryam Nikoonezhad, Abbas Hajifathali, Masoud Soleimani,
Volume 31, Issue 203 (12-2021)
Abstract

Background and purpose: Autologous hematopoietic stem cell transplantation may be one of the best treatment options for some patients with hematological malignancies. The process of stem cell homing in the bone marrow and the production and proliferation of denovo cell populations is called engraftment and could be considered as one of the key factors in the success of stem cell transplantation. The aim of this study was to investigate the main success factors in stem cell transplantation.
Materials and methods: In this retrospective research, patients undergoing autologous stem cell transplantation (between 2009 and 2019) with lymphoma and multiple myeloma were included and the factors affecting engraftment time and the hospital length of stay were studied using patients' records.
Results: In patients with Hodgkin's diagnosis, myeloid engraftment took longer than that in patients with multiple myeloma (P= 0.06). One-unit increase in platelet transfusion led to late myeloid engraftment (P= 0.09). Patients diagnosed with Hodgkin lymphoma also had a later platelet engraftment than patients diagnosed with multiple myeloma (P= 0.008) and increase in unit of platelets transfused caused later platelet engraftment (P= 0.05). Significant risk factors in multivariate analysis were entered into multiple models, among which only the number of packed cells transfusion was associated with duration of hospitalization (P<0.0001).
Conclusion: Myeloid and platelet engraftment are associated with numbers of transfusions and transfusion support should be provided for patients at the correct rate to avoid hospital length of stay. 

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