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Showing 2 results for Multiple Drug Resistance
Multidrug and Cross-resistance Pattern of ESBL-producing Enterobacteriaceae Agents of Nosocomial Infections in Intensive Care Units
Mohammad Sadegh Rezai, Masoumeh Bagheri-Nesami, Azin Hajalibeig, Fatemeh Ahangarkani,
Volume 26, Issue 144 (1-2017)
Abstract

Background and purpose: Multiple drug resistance in Enterobacteriaceae has restricted the available options for treatment of infections caused by these bacteria. The aim of this study was to investigate the pattern of multidrug resistance and cross-resistance in Enterobacteriaceae causing nosocomial infections in intensive care units during 2014-2015 in eighteen governmental hospitals in Mazandaran province, Iran.

Materials and methods: A cross-sectional descriptive study was performed in which antibiotic susceptibility test to routinely antibiotics was determined by MIC method and "broth micro-dilution” was done according to CLSI.

Results: A total of 35 strains including Klebsiella pneumoniae (24), Escherichia coli (6), and Enterobacter spp (5) were extended-spectrum β-lactamases producer. The prevalence of multidrug resistance in Klebsiella pneumoniae, Escherichia coli and Enterobacter spp were 95.83%, 66.6%, and 80%, respectively. Among the isolates 28.57% exhebited cross-resistance to aminoglycoside antibiotics and 40% were found with cross-resistance to third- and fourth-generation cephalosporins.

Conclusion: Regarding the high prevalence of multidrug resistance and the emergence of cross-resistance to different categories of antibiotics among Enterobacteriaceae causing nosocomial infection, more effective measures should be taken including implementation of infection control programs, isolation of patients infected by multidrug resistance bacteria, and antibiotic stewardship in hospitals.


Investigating the Prevalence and Antibiotic Resistance Pattern of Nosocomial Bacterial Infections in Imam Khomeini Hospital, Sari
Roya Ghasemian, Elnaz Nasiri Parman, Golnar Rahimzadeh,
Volume 33, Issue 224 (9-2023)
Abstract
 Background and purpose: Nosocomial infections are considered as a significant problem in medical centers, causing a high mortality rate among hospitalized patients, increasing the duration of hospitalization and treatment costs. Most nosocomial infections are caused by gram-negative bacteria. These bacteria are resistant to a wide range of antibiotics through changing their genetics and structure. The purpose of this study was to investigate the prevalence and pattern of antibiotic resistance of nosocomial bacterial infections at Imam Khomeini Hospital in Sari, during 2019.
Materials and methods: This retrospective descriptive cross-sectional study was performed at Imam Khomeini Hospital in Sari during 2019. All isolated positive samples were selected from hospitalized patients. Antibiotic resistance pattern was investigated using disk fusion method (Kirby-Bauer).
Results: In this study, the most frequent nosocomial infection was observed in the intensive care unit (ICU), with respiratory infection (42%), as the most frequent one, caused by Escherichia coli (25%) with the highest resistance to ciprofloxacin.
Conclusion: The findingins showed that gram-negative bacteria, more specifically those resistant to cephalosporins, are the most common cause of nosocomial infections. Irrational and imprudent prescription of cephalosporins and carbapenems may be a significant contributor to antibiotic resistance and the main challenge for treating.
 
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