fa بررسی آلودگی سطوح با داروهای سیکلوفسفامید و ایفسفامید در مراکز کموتراپی بهداشت حرفه ای Health Professiona پژوهشي-کامل Research(Original) <span style="letter-spacing:-.1pt;"><span style="color:black;"><span style="font-family:b koodak;">سابقه</span></span></span><span style="letter-spacing:-.1pt;"><span style="color:black;"><span style="font-family:b koodak;"> و هدف:</span></span></span><span style="font-family:b zar;"> داروهای</span> <span style="font-family:b zar;">سیکلوفسفامید</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">ایفسفامید</span> <span style="font-family:b zar;">دو</span> <span style="font-family:b zar;">داروی</span> <span style="font-family:b zar;">پرکاربرد</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">خطرناک</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">مراکز</span> <span style="font-family:b zar;">کموتراپی</span> <span style="font-family:b zar;">می</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">باشند</span><span style="font-family:b zar;">. </span><span style="font-family:b zar;">هدف</span> <span style="font-family:b zar;">از انجام</span><span style="font-family:b zar;"> مطالعه حاضر</span><span style="font-family:b zar;">،</span> <span style="font-family:b zar;">تعیین</span> <span style="font-family:b zar;">میزان</span> <span style="font-family:b zar;">آلودگی</span> <span style="font-family:b zar;">سطوح مراکز</span> <span style="font-family:b zar;">کموتراپی</span> <span style="font-family:b zar;">با</span> <span style="font-family:b zar;">داروهای</span> <span style="font-family:b zar;">سیکلوفسفامید</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">ایفسفامید</span> <span style="font-family:b zar;">بود.</span><br> <span style="letter-spacing:-.1pt;"><span style="color:black;"><span style="font-family:b koodak;">مواد و روش</span></span></span><span style="letter-spacing:-.1pt;"><span style="color:black;"><span style="font-family:b zar;">‌</span></span></span><span style="letter-spacing:-.1pt;"><span style="color:black;"><span style="font-family:b koodak;">ها:</span></span></span> <span style="font-family:b zar;">این</span> <span style="font-family:b zar;">مطالعه</span> <span style="font-family:b zar;">توصیفی</span> <span style="font-family:b zar;">مقطعی</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">سال</span><span style="font-family:b zar;"> 1395 </span><span style="font-family:b zar;">در</span> <span style="font-family:b zar;">سه</span> <span style="font-family:b zar;">مرکز</span><span style="font-family:b zar;"> کموتراپی</span> <span style="font-family:b zar;">دانشگاه</span> <span style="font-family:b zar;">علوم</span> <span style="font-family:b zar;">پزشکی</span> <span style="font-family:b zar;">همدان</span> <span style="font-family:b zar;">انجام</span> <span style="font-family:b zar;">شد.</span> <span style="font-family:b zar;">بدین</span> <span style="font-family:b zar;">منظور</span><span style="font-family:b zar;">، </span><span style="font-family:b zar;">28 نمونه از</span> <span style="font-family:b zar;">سطوح</span> <span style="font-family:b zar;">آلوده جمع</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">آوری و</span> <span style="font-family:b zar;">بعد</span> <span style="font-family:b zar;">از</span> <span style="font-family:b zar;">آماده</span> <span style="font-family:b zar;">سازی</span> <span style="font-family:b zar;">با</span> <span style="font-family:b zar;">روش</span> <span style="font-family:b zar;">استخراج</span> <span style="font-family:b zar;">فاز</span> <span style="font-family:b zar;">جامد،</span> <span style="font-family:b zar;">توسط</span> <span style="font-family:b zar;">دستگاه</span> <span dir="LTR"><span style="font-size:10.0pt;">HPLC/UV</span></span> <span style="font-family:b zar;">تجزیه</span> <span style="font-family:b zar;">گردید</span><span style="font-family:b zar;">.</span><br> <span style="letter-spacing:-.2pt;"><span style="color:black;"><span style="font-family:b koodak;">یافته</span></span></span><span style="letter-spacing:-.2pt;"><span style="color:black;"><span style="font-family:b zar;">‌</span></span></span><span style="letter-spacing:-.2pt;"><span style="color:black;"><span style="font-family:b koodak;">ها:</span></span></span> <span style="font-family:b zar;">میانگین</span> <span style="font-family:b zar;">میزان</span> <span style="font-family:b zar;">آلودگی</span> <span style="font-family:b zar;">سیکلوفسفامید</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">ایفسفامید</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">سطوح</span> <span style="font-family:b zar;">به</span> <span style="font-family:b zar;">ترتیب</span><span style="font-family:b zar;"> 8/63 </span><span style="font-size:10.0pt;">&plusmn;</span><span style="font-family:b zar;">28/57 </span><span style="font-family:b zar;">و</span><span style="font-family:b zar;"> 5/5</span><span style="font-size:10.0pt;">&plusmn;</span><span style="font-family:b zar;">15/44 </span><span style="font-family:b zar;">نانوگرم</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">سانتی</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">مترمربع</span> <span style="font-family:b zar;">به</span> <span style="font-family:b zar;">دست</span> <span style="font-family:b zar;">آمد</span><span style="font-family:b zar;">. </span><span style="font-family:b zar;">بیش</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">ترین</span> <span style="font-family:b zar;">میزان</span> <span style="font-family:b zar;">آلودگی</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">سطوح</span> <span style="font-family:b zar;">زیر</span> <span style="font-family:b zar;">هود</span><span style="font-family:b zar;"> و </span><span style="font-family:b zar;">کم</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">ترین</span> <span style="font-family:b zar;">آن</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">ایستگاه</span> <span style="font-family:b zar;">پرستاری</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">محل</span> <span style="font-family:b zar;">استراحت</span> <span style="font-family:b zar;">کارکنان مشاهده</span> <span style="font-family:b zar;">گردید</span><span style="font-family:b zar;">. </span><span style="font-family:b zar;">نتایج</span> <span style="font-family:b zar;">هم</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">چنین</span> <span style="font-family:b zar;">حاکی</span> <span style="font-family:b zar;">از</span> <span style="font-family:b zar;">وجود</span> <span style="font-family:b zar;">آلودگی</span><span style="font-family:b zar;"> در </span><span style="font-family:b zar;">لباس</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">دستکش</span> <span style="font-family:b zar;">پرستاران</span> <span style="font-family:b zar;">بود</span><span style="font-family:b zar;">.</span><br> <span style="letter-spacing:-.2pt;"><span style="color:black;"><span style="font-family:b koodak;">استنتاج:</span></span></span><span style="font-family:b zar;"> نتایج نشان داد که </span><span style="font-family:b zar;">میزان مصرف</span> <span style="font-family:b zar;">روزانه داروها،</span> <span style="font-family:b zar;">موقعیت قرار گیری</span> <span style="font-family:b zar;">اتاق</span> <span style="font-family:b zar;">آماده</span> <span style="font-family:b zar;">سازی و</span> <span style="font-family:b zar;">تزریق</span> <span style="font-family:b zar;">دارو،</span> <span style="font-family:b zar;">ایستگاه</span> <span style="font-family:b zar;">پرستاری</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">محل</span> <span style="font-family:b zar;">استراحت</span> <span style="font-family:b zar;">کارکنان</span><span style="font-family:b zar;"> و هم</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">چنین برنامه </span><span style="font-family:b zar;">نظافت</span> <span style="font-family:b zar;">روزانه، تعمیر</span> <span style="font-family:b zar;">و</span> <span style="font-family:b zar;">نگهداشت</span> <span style="font-family:b zar;">سیستم</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">های</span> <span style="font-family:b zar;">تهویه</span> <span style="font-family:b zar;">موضعی،</span> <span style="font-family:b zar;">مهم</span><span style="font-family:b zar;">‌</span><span style="font-family:b zar;">ترین</span> <span style="font-family:b zar;">عوامل</span> <span style="font-family:b zar;">تاثیرگذ</span><span style="font-family:b zar;">ار</span> <span style="font-family:b zar;">بر</span> <span style="font-family:b zar;">آلودگی سطوح</span> <span style="font-family:b zar;">در</span> <span style="font-family:b zar;">مراکز</span> <span style="font-family:b zar;">کموتراپی</span> <span style="font-family:b zar;">می</span> <span style="font-family:b zar;">باشد</span><span style="font-family:b zar;">.</span><br> &nbsp; &nbsp;<br> <strong>Background and purpose:</strong> Cyclophosphamide and ifosfamide are two most widely used and hazardous drugs in chemotherapy centers. This study aimed at determining surface contamination with cyclophosphamide and iphosphamide in chemotherapy centers.<br> <strong>Materials and methods:</strong> This descriptive cross-sectional study was carried out in three chemotherapy centers affiliated with Hamedan University of Medical Sciences, Iran 2016. Twenty eight samples were collected from contaminated surfaces. The samples were then prepared by solid phase extraction and analyzed by HPLC/UV apparatus.<br> <strong>Results:</strong> The mean values for surface contamination of cyclophosphamide and ifosfamide were 57.28 &plusmn; 63.8 and 44.15 &plusmn; 5.5 ng/cm², respectively. The highest levels of contamination with both drugs were observed at exhaust hood surfaces and the lowest level of contamination was seen in nursing station and staff resting place. The clothes and gloves of nurses were also found to be contaminated.<br> <strong>Conclusion:</strong> Daily number of medications, the location of drug preparation room and injection room, nursing station, staff resting place, daily cleaning programs, and repairing and maintenance of ventilation systems were amongst the major factors affecting surface contamination in chemotherapy centers.<br> &nbsp; دارو درمانی, سیکلوفسفامید, ایفسفامید, مواجهه شغلی, پایش محیطی, بیمارستان‌ها drug therapy, cyclophosphamide, ifosfamide, occupational exposure, environmental monitoring, hospitals 133 137 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-8379-1&slc_lang=fa&sid=1 Hamideh Deljou حمیده دلجو 100319475328460091863 100319475328460091863 No MSc Student in Occupational Hygiene, Center of Excellence for Occupational Health, Research Center for Health Sciences, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran دانشجوی کارشناسی ارشد مهندسی بهداشت حرفه ای، قطب علمی آموزشی بهداشت حرفه ای، مرکز تحقیقات علوم بهداشتی، دانشکده بهداشت، دانشگاه علوم پزشکی همدان، همدان، ایران Mohammad Javad Assari محمد جواد عصاری Asari@umsha.ac.ir 100319475328460091864 100319475328460091864 Yes Assistant Professor, Center of Excellence for Occupational Health, Research Center for Health Sciences, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran استادیار، قطب علمی آموزشی بهداشت حرفه ای، مرکز تحقیقات علوم بهداشتی، دانشکده بهداشــت، دانشگاه علوم پزشکی همدان، همدان، ایران Abdolraman Bahrami عبدالرحمن بهرامی 100319475328460091865 100319475328460091865 No Professor, Center of Excellence for Occupational Health, Occupational Safety and Health Research Center, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran استاد، قطب علمی آموزشی بهداشت حرفه ای، مرکز تحقیقات بهداشت و ایمنی شغلی، دانشکده بهداشت، دانشگاه علوم پزشکی همدان، همدان، ایران Mohammad Zolhavarieh محمد ذوالحواریه 100319475328460091866 100319475328460091866 No Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran استادیار، گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران