Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2022
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ارزیابی سطوح ویسفاتین مایع شیار لثه ای در بیماران مبتلا به سرطان اندومتر و پریودنتیت مزمن درمقایسه با افراد سالم
Comparing Gingival Crevicular Fluid Visfatin Levels Between Patients with Endometrial Cancer and Chronic Periodontitis and Healthy Controls
دندانپزشکی
Dentistry
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="line-height:87%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ارتباط بین بیماری</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">های پریودنتال و سرطان اندومتر در برخی از مطالعات بررسی شده است. هرچند که نقش عوامل التهابی نظیر ویسفاتین در این رابطه ناشناخته است. این مطالعه با هدف ارزیابی ویسفاتین مایع شیار لثه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ای در بیماران مبتلا به سرطان اندومتر و پریودنتیت مزمن انجام شد.</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:87%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">مطالعه حاضر یک مطالعه مورد شاهدی همسان شده از نظر سن و شاخص توده بدن بود. 120 زن مورد مطالعه به چهار گروه تقسیم شدند. گروه بیمار شامل مبتلا به سرطان اندومتر و پریودنتیت مزمن (گروه یک=20 نفر) و مبتلا به سرطان اندومتر و سالم از نظر پریودنتیت مزمن (گروه دو=20 نفر) و گروه سالم شامل سالم از نظر ابتلا به سرطان اندومتر و مبتلا به پریودنتیت مزمن (گروه سه=40 نفر) و سالم از نظر هر دو بیماری (گروه چهار=40 نفر). مایع شیار لثه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ای جمع</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">آوری و توسط الایزا ارزیابی شد.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:87%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">پارامترهای پریودنتال نظیر عمق پاکت پریودنتال، از دست رفتن اتصالات بالینی و درصد خونریزی در حین پروب در گروه یک نسبت به سایر گروه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ها به</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">طور معنی</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">داری بیش</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">تر بود (0/001</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">></span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:87%"><span style="color:black">P</span></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">). میانگین ویسفاتین مایع شیار لثه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ای در گروه یک تفاوت معنی</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">داری با گروه دو و چهار داشت (0/001</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">></span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:87%"><span style="color:black">P</span></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">). همچنین میانگین ویسفاتین مایع شیار لثه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ای در گروه سه نیز تفاوت معنی</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">داری با گروه چهار داشت (0/001</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">></span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:87%"><span style="color:black">P</span></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">).</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:87%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">یافته</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">های مطالعه حاضر نشان</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">دهنده نقش احتمالی ویسفاتین مایع شیار لثه</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black">ای در ارتباط بین سرطان اندومتر و پریودنتیت مزمن در شرایط التهابی است.</span></span></span><span lang="AR-SA" style="line-height:87%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
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<strong> </strong><span style="font-size:12pt"><span style="line-height:135%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:135%"><span style="letter-spacing:-.2pt">The association between periodontal diseases and endometrial cancer (EC) has been assessed in some studies but the probable role of inflammatory factors such as visfatin is unknown. This study aimed at evaluating the levels of visfatin in gingival crevicular fluid (GCF) in patients with EC and chronic periodontitis (CP) to address this gap.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:135%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:135%">In a case-control study with matched </span></span><span style="font-size:10.0pt"><span style="line-height:135%"><span style="letter-spacing:-.2pt">age and body mass index controls, 120 female participants were divided into four groups. Case groups included group I (EC-CP [n=20]), group II (EC without CP [n=20]), and controls were group III (without EC but diagnosed with CP [n=40]), and group IV (healthy without EC or CP [n=40]). GCF samples were collected and visfatin was assessed by enzyme-linked immunosorbent assay.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:135%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:135%"><span style="letter-spacing:-.2pt">Clinical periodontal parameters such as periodontal pocket depth, clinical attachment loss, and bleeding on probing were significantly higher in EC-CP group than other groups (P<0.001). Mean visfatin level in GCF was found to be significantly different in group I compared with groups II and IV (P<0.001). Also, there was a significant difference in visfatin concentration in GCF between group III and group IV (P<0.001).</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:135%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:135%"> <span style="letter-spacing:-.2pt">According to current study, GCF visfatin concentration is probably associated with EC and CP.</span></span></span></span></span></span></span><br>
پریودنتیت مزمن, سرطان اندومتر, مایع شیار لثهای, ویسفاتین
chronic periodontitis, endometrial cancer, gingival crevicular fluid, visfatin
48
58
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-11669-9&slc_lang=fa&sid=1
Mohammad
Moazen
محمد
موذن
mohammadmoazzen0@gmail.com