Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2022
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اثر کورکومین بر درمان لیکن پلان دهانی
(یک کارآزمایی بالینی تصادفی کنترل شده تک سوکور)
Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial
دندانپزشکی
Dentistry
پژوهشي-کامل
Research(Original)
<strong><span dir="RTL"> </span></strong><span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black">سابقه</span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"> و هدف:</span></span></span> <span lang="AR-SA" style="font-family:"B Zar"">به دلیل </span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">اهمیت درمان لیکن پلان و استفاده از ترکیبات گیاهی بومی مؤثر و معرفی درمانی نوین و مقرون به صرفه، با عوارض جانبی کمترنسبت به کورتیکوستروئیدها و با توجه به محدودیت در تولید داروهای شیمیایی در شرایط کنونی</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">،</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""> این مطالعه با هدف بررسی اثر کورکومین بر درمان لیکن پلان دهانی انجام شد.</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak"">مواد و روش</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak"">ها:</span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">تعداد 28 بیمار مبتلا به لیکن پلان دهانی به صورت مستمر انتخاب و به شکل تصادفی به دو گروه مداخله وپلاسبو تقسیم شدند.14</span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">بیمار درمان دارویی موضعی با کورتیکواسترو</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">ئ</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">ید وداروی ضدقارچ به همراه یک عدد کپسول سینا کورکومین و 14 بیمار دیگر کورتیکواستروئید و داروی ضد قارچ به همراه یک عدد کپسول<sub> </sub> پلاسبو به مدت یک ماه دریافت کردند.</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak"">یافته</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak"">ها:</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> نتایج از لحاظ </span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">شکل ظاهری قبل از درمان (0/227=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">،</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""> 2 هفته بعد از درمان (0/031=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">، </span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">4 هفته بعد از درمان (0/0001=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)، درد و سوزش قبل از درمان (0/769=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)، 2 هفته بعد از درمان</span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">(0/0797=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">)</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">، 4هفته بعد از درمان (0/019=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)</span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">تفاوت معنادار داشتند و به لحاظ سایز ضایعه، در طول زمان تفاوت معن</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">ی</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">داری بین 2 گروه یافت نشد (قبل از درمان (0/349=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)، 2 هفته بعد از درمان (0/213=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)، 4هفته بعد از درمان (0/123=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">) ).</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak"">استنتاج:</span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">بهبود شاخصهای درد وسوزش وشکل ظاهری، در گروه مداخله نسبت به گروه پلاسبو مشاهده شد و به لحاظ کاهش سایز ضایعه میان دو گروه تفاوت آماری معنیداری گزارش نشد. بنابراین میتوان کورکومین را مادهای موثر در بهبود لیکن پلان دهانی دانست</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">.</span></span></span></span></span></span></span></span></span><br>
<strong> </strong><span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Background and purpose:</span></span></span></b> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">Lichen planus management requires introducing effective local herbal ingredients and cost-effective treatments with fewer side effects compared with corticosteroids. Due to current condition and restrictions in making chemical drugs this study was done to investigate the effect of curcumin on oral lichen planus. </span></span></span></span></span>
<pre style="text-align:justify; text-indent:28.05pt">
<span style="font-size:10pt"><span style="line-height:150%"><span style="font-family:"Courier New""><b><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></b><b> </b><span lang="EN" style="font-family:"Times New Roman","serif"">In a <span style="letter-spacing:-.3pt">randomized controlled clinical trial, 28 patients with oral lichen planus were selected sequentially and were randomly divided into an intervention group and a placebo group (n= 14 per group).</span> </span><span lang="EN" style="font-family:"Times New Roman","serif"">Patients in intervention group received topical corticosteroid, antifungal medication, and one Sina Curcumin capsule for a month. In placebo group, the patients were given corticosteroid, antifungal medication, and one placebo capsule for the same duration.</span></span></span></span></pre>
<pre style="text-align:justify; text-indent:28.05pt">
<span style="font-size:10pt"><span style="line-height:150%"><span style="font-family:"Courier New""><b><span style="font-family:"Arial","sans-serif"">Results:</span></b><b> </b><span lang="EN" style="font-family:"Times New Roman","serif"">There were significant differences in appearance of lesions and pain before treatment (P=0.227 and P=0.769, respectively), two weeks after treatment (P=0.031 and P= 0.0497), and four weeks after treatment (P=0.0001 and P= 0.019). Lesion size did not show significant differences between the two groups before (P=0.349), two weeks after (P=0.213), and four weeks after treatment (P=0.123).</span></span></span></span></pre>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">In the present study, pain and appearance of lesions improved in intervention group but lesion size was not found to improve significantly. According to current study, curcumin can be considered as an effective agent in treatment of oral lichen planus.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
کورکومین, لیکن پلان دهانی, کورتیکواستروئید
curcumin, oral lichen planus, corticosteroid
37
48
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-14822-1&slc_lang=fa&sid=1
Nazanin
Ghobadi
نازنین
قبادی
nazaninghobadi7@gmail.com