Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
1
admin
1735-9260
1735-9279
fa
jalali
1401
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2022
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بررسی فراوانی و عوامل موثر بر قطع درمان در بیماران مبتلا به بیماری های التهابی روماتیسمی
Frequency and Effective Factors on Discontinuation of Treatment in Patients with Inflammatory Rheumatic Diseases
روماتولوژی
Gynecology and Infertility
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">درمان بیماری</span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">های روماتیسمی بستگی به مصرف مناسب داروها دارد. این مطالعه با هدف بررسی فراوانی</span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""> و دلایل قطع داروها در این بیماران روماتیسمی انجام پذیرفت.</span></span><span lang="FA" style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">این </span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">مطالعه مقطعی، در سال های 1398-1400 در شهر ساری در بیماران مبتلا به بیماری</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">های التهابی روماتیسمی به منظور بررسی میزان فراوانی قطع دارو و دلایل آن انجام شد. آنالیز آماری با استفاده از نرمافزار </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">SPSS 20</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""> و برای تعیین فراوانی قطع دارو و عوامل آن از روش</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">های آمار توصیفی استفاده گردید. 0/05 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P<</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> معنی</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">دار در نظر گرفته شد.</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">251 بیمار شامل </span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">197 بیمار</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">آرتریت روماتوئید، 31 بیمار لوپوس سیستمیک، 16 بیمار اسپوندیلیت انکیلوزان و 7 بیمار آرتریت پسوریازیس وارد مطالعه شدند. </span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">میانگین سن بیماران 13/4 </span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%">±</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> 52/36</span></span> <span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">و مدت بیماری 7/31 </span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%">±</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> 8/35 سال بود. </span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">به</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">طور کلی 73 بیمار، 85 مورد قطع دارو داشتند که شایعترین علت قطع دارو، عوارض جانبی دارو بود که در </span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">55/4 درصد بیماران اتفاق افتاد. عدم موجودی در بازار دارویی، بهبودی موقت علایم بیماری، موثر نبودن دارو و نگرانی از ابتلا به کووید 19 از علل قطع دارو بود.</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">شایع</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">ترین علت قطع درمان، عوارض دارویی است ولی در حدود یک سوم موارد، عوامل قابل اصلاحی هستند که شناخت آن</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">ها می</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">تواند در پیشگیری از قطع دارو ها و عدم پایبندی به درمان، کمک</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">کننده باشد.</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Treatment of rheumatic diseases depends on proper use of medications. The aim of this study was to evaluate the frequency and reasons for discontinuation of drugs in these patients.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">A cross-sectional study was performed in patients with inflammatory rheumatic diseases in Sari, Iran 2020-2021 to investigate the frequency and reasons for discontinuation of drugs. Statistical analysis was performed using SPSS V20 and descriptive statistical methods were used to determine the frequency of drug discontinuation and its causes. </span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">The participants (n=251) included<b> </b></span></span><span style="font-size:10.0pt"><span style="line-height:150%">197 patients with rheumatoid arthritis, 31 with systemic lupus, 16 with ankylosing spondylitis, and 7 patients with psoriatic arthritis. The mean age of patients was 52.36</span></span><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span style="line-height:150%">±</span></span><span style="font-size:10.0pt"><span style="line-height:150%">13.4 and mean duration of illness was 8.35</span></span><span dir="RTL" lang="AR-SA" style="font-size:10.0pt"><span style="line-height:150%">±</span></span><span style="font-size:10.0pt"><span style="line-height:150%">7.31 years. Drug discontinuation was seen in 73 patients (85 cases). The most common reason for drug discontinuation was drug side effects (55.4%). Drug shortage, transient improvement of symptoms, ineffectiveness of the drug, and fear of developing COVID 19 were some of the reasons for discontinuation of drug.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">The most common cause of discontinuation of treatment was drug side effects, but in about one third of cases, there are factors that could be corrected to help preventing drug discontinuation and non-adherence to treatment.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
کورتیکواستروئید, داروهای ضد روماتیسم, قطع دارو
corticosteroid, antirheumatic agents, drug discontinuation
145
150
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-327-9&slc_lang=fa&sid=1
Maryam
Mobini
مریم
مبینی
mmobini50@yahoo.com
1003194753284600144196
1003194753284600144196
Yes
Associate Professor, Department of Internal Medicine, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
دانشیار، گروه داخلی، مرکز تحقیقات دیابت، دانشگاه علوم پزشکی مازندران، ساری، ایران
Reza Ali
Mohammadpour
رضاعلی
محمدپور
mohammadpour2002@yahoo.com
1003194753284600144197
1003194753284600144197
No
Professor, Department of Biostatistics, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
استاد، گروه آمار زیستی، مرکز تحقیقات دیابت، دانشگاه علوم پزشکی مازندران، ساری، ایران
Mohammad Reza
Biabani
محمد رضا
بیابانی
m.reza_75@yahoo.com
1003194753284600144198
1003194753284600144198
No
Medical Student, Mazandaran University of Medical Sciences, Sari, Iran
دانشجوی پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران