Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2022
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مقایسه بیان ایمونوهیستوشیمیایی پودوپلانین بین کارسینوم سلول سنگفرشی دهان و مخاط نرمال دهان
Comparing Immunohistochemical Expression of Podoplanin between Oral Squamous Cell Carcinoma and Normal Oral Mucosa
آسيب شناسي(پاتولوژی)
Pathology
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="font-family:"B Zar"">کارسینوم سلول </span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">سنگفرشی دهان (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">OSCC</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">)، ششمین سرطان شایع در جهان است. پودوپلانین یک گلیکوپروتئین شبه موسینی در ضخامت غشا است که در اندوتلیوم لنفاوی بیان شده اما در اندوتلیوم عروق خونی بیان نمیشود. هدف از مطالعه حاضر، بررسی بیان ایمونوهیستوشیمیایی پودوپلانین و بررسی لنفانژیوژنز در کارسینوم سلول سنگفرشی دهان در مقایسه با مخاط نرمال دهان بود.</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">در این مطالعه آزمایشگاهی، ۴۰ بلوک پارافینه از بایگانی بخش پاتولوژی دهان، فک و صورت دانشکده دندانپزشکی بابل با </span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">تشخیص قبلی کارسینوم سلول سنگفرشی دهان و ۴۰ نمونه از مخاط نرمال دهان که طی جراحی دندان عقل نهفته به دست آمده بود با حداقل التهاب از دید بافتی و هیستوپاتولوژی، وارد مطالعه شدند و بیان ایمونوهیستوشیمیایی پودوپلانین در سلول</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">های اپی</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">تلیالی دو گروه و تعداد عروق لنفاوی در آن</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">ها مورد ارزیابی قرار گرفت. جهت آنالیز داده</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">ها از آزمونهای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Chi-sqaure</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Mann-Whitney</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Wilcoxon</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Oneway ANOVA</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> استفاده شد. </span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">اختلاف میانگین تعداد عروق لنفی در ناحیه تهاجم تومور در گروه </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">OSCC</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> (2/02</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span style="font-family:"Cambria","serif"">±</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">4/43) و در مرکز تومور (78/72</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"Cambria","serif"">±</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">6/2) به لحاظ آماری معنادار بود (0/001</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span style="font-family:"B Zar"">></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">). در بررسی بیان پودوپلانین از نظر کیفی بین دو گروه مشخص شد که در گروه </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">OSCC</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> بیان پودوپلانین در 23 مورد (57/5 درصد) بین 51 تا 100 درصد بوده است. در حالی که در گروه کنترل تنها 4 مورد (10 درصد) از نمونه</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">ها این میزان بیان را داشته</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">اند. بیان پودوپلانین در سلول</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">های اپی</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">تلیالی در کارسینوم سلول سنگفرشی به</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">طور معنی</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">داری بیش از مخاط نرمال دهان بود (0/001</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span style="font-family:"B Zar"">></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">).</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="font-family:"B Zar"">نتایج مطالعه حاضر نقش پودوپلانین را در پاتوژنز کارسینوم سلول سنگفرشی دهان مطرح می</span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="font-family:"B Zar"">نماید.</span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. Podoplanin is a mucin-like integral membrane glycoprotein that is expressed in the lymphatic endothelial cells but not in the blood vascular endothelial cells. The aim of the present study was to investigate the immunohistochemical expression of podoplanin and evaluating lymphangiogenesis in OSCC compared with normal oral mucosa.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">In this laboratory study, 40 paraffin blocks archived in the Department of Oral and Maxillofacial Pathology in Babol Dental School with previous diagnosis of OSCC were used. Also, 40 samples of normal oral mucosa obtained during impacted wisdom tooth surgery with minimal inflammation from histological and histopathological point of view were included. Immunohistochemical expression of podoplanin in epithelial cells and the number of lymphatic vessels were evaluated in both groups. Chi-square, Mann-Whitney, Wilcoxon, and Oneway ANOVA were applied for data analysis. </span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">Findings showed significant difference in the mean number of lymph vessels between the area of tumor invasion in OSCC group (4.43±2.02) and center of the tumor (6.78±2.72) (P<0.001). In the study of podoplanin expression in terms of quality, it was found that in the OSCC group, podoplanin expression was between 51% and 100% in 23 cases (57.5%), while these expression levels in the control group were seen only in four cases (10%). Podoplanin expression in epithelial cells in squamous cell carcinoma was significantly higher than normal oral mucosa (P<0.001).</span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">The present study suggests that podoplanin is involved in the pathogenesis of oral squamous cell carcinoma.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
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<strong><span dir="RTL"></span></strong>
پودوپلانین, کارسینوم سلول سنگفرشی دهان, مخاط دهان, ایمونوهیستوشیمیایی
podoplanin, oral squamous cell carcinoma, oral mucosa, immunohistochemistry
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47
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-705-3&slc_lang=fa&sid=1
Samareh
Jazayeri
ثمره
جزایری
S_jazayeri@yahoo.com
1003194753284600145818
1003194753284600145818
No
Dental Student, Student Research Committee, Babol University of Medical Sciences, Babol, Iran
دانشجوی دندانپزشکی، کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بابل، بابل، ایران
Maryam
Seyedmajidi
مریم
سیدمجیدی
ms_majidi79@yahoo.com
1003194753284600145819
1003194753284600145819
Yes
Professor, Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
استاد، مرکز تحقیقات مواد دندانی، پژوهشکده سلامت، دانشگاه علوم پزشکی یایل، بابل، ایران
Fatima
Bijani
فاطمه
بیژنی
fatimahb56@gmail.com
1003194753284600145820
1003194753284600145820
No
Assistant Professor, Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
استادیار، مرکز تحقیقات سلامت دهان، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل ایران
Seyedali
Seyedmajidi
سیدعلی
سیدمجیدی
s.majidi.dvm@gmail.com
1003194753284600145821
1003194753284600145821
No
Assistant Professor, Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
استادیار، مرکز تحقیقات مواد دندانی، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران