Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2024
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الگوی مقاومت آنتی بیوتیکی عوامل باکتریال جدا شده از کشت خون بیماران مبتلا به اندوکاردیت عفونی در مراکز آموزشی-درمانی دانشگاه علوم پزشکی مازندران
Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis
عفوني
infection
پژوهشي-کامل
Research(Original)
<span style="font-size:16px;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span b="" style="font-family:" zar=""><span style="color:black">توجه به این که آگاهی از میزان شیوع عفونتهای باکتریایی و نوع باکتریهای دخیل در ایجاد اندوکاردیت و دانستن الگوی مقاومت آنتی</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">بیوتیکی آن</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">ها برای انتخاب صحیح آنتی</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">بیوتیک</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">ها جهت درمان این عفونتها در بیمارستان بسیار اهمیت دارد، بنابراین این مطالعه با هدف بررسی الگوی مقاومت آنتی</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">بیوتیکی عوامل باکتریال جدا شده از کشت خون بیماران مبتلا به اندوکاردیت عفونی، پرداخته شد.</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span b="" style="font-family:" zar=""><span style="color:black">این مطالعه توصیفی- مقطعی گذشتهنگر، بر روی </span></span><span b="" style="font-family:" zar=""><span style="color:black">بیماران مبتلا به اندوکاردیت عفونی بستری شده در بیمارستان فاطمه</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">الزهرا ساری و بیمارستان رازی قائمشهر بین سال</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">های 1402 - 1398 انجام گرفت</span></span><span b="" style="font-family:" zar=""><span style="color:black">.</span></span><span b="" style="font-family:" zar=""><span style="color:black"> داده</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">ها پس از جمع</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span b="" style="font-family:" zar=""><span style="color:black">آوری با استفاده از نرم افزار </span></span><span dir="LTR"><span style="color:black">SPSS</span></span><span b="" style="font-family:" zar=""><span style="color:black"> نسخه 19، مورد تجزیه و تحلیل قرار گرفت.</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">در مجموع 28 بیمار وارد مطالعه شدند که از این میان ۱۶ بیمار (57/1 درصد) مرد و 12 بیمار (43/9 درصد) زن بودند و میانگین سنی آنها برابر 13/41</span></span></span><span lang="FA"><span cambria="" style="font-family:"><span style="color:black">±</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">56/ 79 سال بود. بیش</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">ترین میکروارگانیسم جدا شده <i>استافیلوکوکوس اورئوس</i> با 11 نمونه مثبت (39/2 درصد) بود. هم</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">چنین <i>استافیلوکوکوس اورئوس</i> و <i>استافیلوکوکوس اپیدرمیدیس</i> بیش</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">ترین مقاومت دارویی را نشان دادند. نتیجه درمان با هیچ</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">یک از موارد جنسیت، نوع دریچه و نوع میکروارگانیسم جدا شده ارتباط معنی</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">داری نداشت (به ترتیب0/624=</span></span></span><span dir="LTR"><span style="color:black">P</span></span><span lang="PRS-AF"><span b="" style="font-family:" zar=""><span style="color:black">، 1/000=</span></span></span><span dir="LTR"><span style="color:black">P</span></span><span lang="PRS-AF"><span b="" style="font-family:" zar=""><span style="color:black"> و 0/398=</span></span></span><span dir="LTR"><span style="color:black">P</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">).</span></span></span></span></span></span><br>
<span dir="RTL" lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">استنتاج:</span></span></span></span> <span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">در این مطالعه، باکتری</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">های گرم مثبت شاﻳﻊ</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">ﺗﺮﻳﻦ ﮔﺮﻭﻩ ﺍﺯ ﻣﻴﻜﺮﻭﺍﺭﮔﺎﻧﻴﺴﻢ</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">ﻫﺎﻱ ایجادکننده اندوکاردیت عفونی بودند. از طرفی، بیش</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">ترین مقاومت نسبت به آنتی</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">بیوتیک</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">های پنی</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">سیلین، سفتازیدیم و سفتریاکسون مشاهده شد که باید در درمان آنتی</span></span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">بیوتیکی تجربی اولیه در بیماران بستری با اندوکاردیت باکتریایی عفونی مورد توجه قرار گرفته شود</span></span></span></span></span></span>
<span style="font-size:16px;"><span style="line-height:2;"><span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></b> The prevalence of bacterial infections and the type of bacteria involved in causing endocarditis and knowing their antibiotic resistance pattern are very important for the correct selection of antibiotics to treat these infections and the proper control of infection in the hospital. In this retrospective cross-sectional descriptive study, we investigated the antibiotic resistance pattern of bacterial agents isolated from blood cultures of patients with infective endocarditis.<span style="line-height:120%"></span></span><br>
<span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:">Materials and methods:</span></b><b> </b>This retrospective study was conducted on patients with infective endocarditis admitted to Razi and Fatemeh Zahra teaching hospitals over the four years from 2019 to 2023. After collecting the data, it was entered into Excel software and then analyzed using SPSS version 19 software.<span style="line-height:120%"></span></span><br>
<span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:">Results:</span></b><b> </b>Among 28 patients included in the study, 57.1% were men and 42.9% were women; the <span style="letter-spacing:-.2pt">median age of patients was 56.79±13.41 years. The most common isolated microorganism was <i>Staphylococcus</i></span><i> aureus</i> with 11 positive samples (39.2%). Ninety-three percent of the studied microorganisms were resistant to at least two drugs. The result of the treatment was not significantly related to any of the gender, type of valve, and type of isolated microorganism (P=0.624, P=1.000 and P=0.398, respectively).<span lang="EN"><span style="line-height:120%"></span></span></span><br>
<b><span arial="" style="font-family:">Conclusion:</span></b> <span new="" roman="" style="font-family:" times="">In this study, gram-positive bacteria were the most common group of microorganisms causing infective endocarditis. A high percentage of resistance was observed against some antibiotics including penicillin, ceftazidime, and ceftriaxone, which should be considered in initial empiric antibiotic therapy among hospitalized patients with infective endocarditis</span></span></span>
آنتیبیوتیک, مقاومت ضد میکروبی, عفونتهای باکتریایی, اندوکاردیت
antibiotic, antimicrobial resistance, bacterial infections, endocarditis
94
103
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-10690-10&slc_lang=fa&sid=1
Ghazale
Hamedani
غزاله
همدانی
gh.hamedani74@gmail.com