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Background and purpose: Nausea and vomiting are common complaints in early gestation. The most severe form of this disorder is hyperemesis gravidarum (HG), which occurs in 1–2% of pregnancies. Some researches showed that special type of HCG influence TSH receptor increase iodine removal. This process could result in chemical hypothyroid. This study investigated the relationship between beta human chorionic gonadotrophin (BHCG) and throyid function with HG among pregnant women admitted to Sari Imam Khomeini Hospital. Materials and methods: This case-control study was performed in 42 patients admitted to for nausea and vomiting whose gestational age was 8-18 weeks. The study was carried out during June 2011 to December 2011. In this rsearch 45 pregnant women enrolled in a control group who were matched for demographic features. The data including demographic features and levels of TSH, T3, FT4 and BHCG was recorded in both groups. It was then analyzed using t-test and chi square test in SPSS. Results: The mean ages of the participants in control group and experimental group were 25.33±5.9 and 23.17±4.28, respectively. Significant differences were seen in levels of TSH, FT4, T3, and BHCG between the two groups. Conclusion: The serum level of BHCG, FT4, and T3 was higher in patients with nausea and vomiting but the level of TSH was lower. There was chemical hypothyroid among the patients but none of the patients had clinical manifestations of hyperthyroidism.

Keywords: BHCG, thyroid function, hyperemesis gravidarum

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