Background and purpose: The duration and intensity of intestinal motility disorder and pain following abdominal surgery vary among patients. Ileus and postportative pain are iatrogenic phenomena influencing the patients’ morbidity, hospital cost and length of stay in hospital. The aim of the present study was to determine the effect of intraperitoneal bupivacaine on postoperative bowel motility and pain. Materials and methods: A double-blind, randomized clinical trial was carried out on 120 candidates of abdominal surgery (appendectomy, cholecystectomy and laparatomy) aged between 15 and 80 years who referred to an educational hospital. The patients were randomly divided into two groups. Patients in case group, the patients received (1mg/kg) bupivacaine 0.5% in 20cc normal salin while the control group received only 30cc normal salin interaperitoneal. Afterwards, some information including nausea, vomiting, anorexia, distension, bowel sound, flatulence and defecation was recorded in six, 12, 18, 24 and 48 hours after surgery. Results: According to the results of this study the group receiving intraperitoneal bupivacaine intestinal motility happened 12-18 hours earlier (P=0.001) and severity of postoperative pain was reported less (P=0.001). Anorexia, vomiting and nausea also decreased in case group (P=0.002). Conclusion: This research indicates that intraperitoneal bupivacaine could reduce postoperative pain, vomiting, nausea, anorexia and may increase intestinal motility.

Keywords: Bupivacaine, intraperitoneal, intestinal motility, postoperative pain

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