Volume 27, Issue 158 (3-2018)                   J Mazandaran Univ Med Sci 2018, 27(158): 45-55 | Back to browse issues page

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Amoian B, Ehsani H, Moghadamnia A, Dabagh Satari F, Ehsani H. Effect of Biocurcumax TM Curcumin (BCM-95) On Treatment of Moderate Chronic Periodontitis. J Mazandaran Univ Med Sci. 2018; 27 (158) :45-55
URL: http://jmums.mazums.ac.ir/article-1-10339-en.html
Abstract:   (2157 Views)

Background and purpose: Controlling inflammation is a major approach in periodontal treatments, but scaling and root planing are not always effective enough. Curcumin is anti-inflammatory and can adjust inflammatory reactions and its efficacy and immunity is proven. The present research aimed at evaluating the potential of Curcumin BCM-95 in treatment of patients with chronic periodontitis.
Materials and methods: In a double blind clinical trial, the clinical parameters including, Gingival Sulcus Bleeding Index (GSBI), Loe and Silness Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) were recorded at the beginning of the study, at week 6, and month 4. In case group, patients with moderate chronic periodontitis who had no systemic disease with at least one periodontal pocket with 4-6mm depth in each quadrant and bleeding on probing were chosen. After scaling and root planing, the patients took 2 Curcumin oral capsules per day for 4 weeks. The patients in the control group were given placebos.
Results: The effect of time was found to be significant in PPD, GI, CAL, and GSBI. Moreover, significant differences were seen between PPD average measurements before medication, at first follow up, and second follow-up (P<0.05). But, in GI, GSBI, and CAL the group effect was not significant. In other words, the reduction was seen in these parameters in both groups but they were not significant.
Conclusion: The effect of Biocurcumax TM Curcumin (BCM-95) was significant in treatment of moderate chronic periodontitis in PPD between the two groups which reduced this parameter.
 

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Type of Study: Research(Original) | Subject: Pharmacy

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