Volume 16, Number 52 (May 2006)                   J Mazandaran Univ Med Sci 2006, 16(52): 33-39 | Back to browse issues page


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Mohiti Ârdakani J. Effect of metformin on the levels of leptin and insulin. J Mazandaran Univ Med Sci. 2006; 16 (52) :33-39
URL: http://jmums.mazums.ac.ir/article-1-122-en.html

Abstract:   (7032 Views)
Background and purpose : Leptin and insulin are secreted from fat and Pancrease tissues respectively. They decrease food consumption and regulate homeostasis of body weight via central nervous system. Metformin is an anti hyperglycemia which is used for treatment of type 2 diabetes. The aim of this study was investigating correlation between leptin and insulin levels before and after treatemnt with metformin in type ÏÏ diabetic patients.
Materials and methods : Ïn this clinical trail, 25 cases type ÏÏ diabetic patients with BMÏ greater than 30 Kg/m2, (mean age 52 ± 12 years) were selected. They received treatment with metformin (1000 mg twice daily) for one month, then a fasting blood sample was taken and analyzed.
Results : Results showed a significant changes in mean of glucose (P<0.05), cholesterol, triglyceride (P<0.05) and LDL in the patients under study before and after treatment (P<0.05). There was no significant change in mean of weight and BMÏ, (P>0.05) fatty mass, free fatty mass, leptin and insulin (P>0.05) before and after treatment.
Çonclusion: The statistical analysis showed that there is a correlation between these two hormones before treatment (P=0.0 , r=0.76), while disappears after treatment probably via making the insulin receptors sensitive and through the other probable mechanisms, decreases glucose and changes the function and the effect of insulin that appeared in non-correlation condition of these two hormones.
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Type of Study: Research(Original) |

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