Volume 22, Issue 91 (7-2012)
J Mazandaran Univ Med Sci 2012, 22(91): 31-38 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Shokrzadeh M, Ahangar N, Abdollahi M, Shadboorestan A, Omidi M, Hosseini payam S S. Evaluating the Effects of Diazinon on Hepatic Glutathione Levels in Rats and Protective Roles of Selenium and L-Carnitine. J Mazandaran Univ Med Sci 2012; 22 (91) :31-38
URL: http://jmums.mazums.ac.ir/article-1-1873-en.html
URL: http://jmums.mazums.ac.ir/article-1-1873-en.html
Mohammad Shokrzadeh 
, Nematollah Ahangar , Mohammad Abdollahi , Amir Shadboorestan , Mahmood Omidi , Sakineh Sadat Hosseini payam
, Nematollah Ahangar , Mohammad Abdollahi , Amir Shadboorestan , Mahmood Omidi , Sakineh Sadat Hosseini payam
Abstract: (16829 Views)
Background and purpose: Widespread use of pesticides in public health and agriculture has caused environmental pollution and increased risk of acute human poisonings. Diazinon is one of the most prevalent organophosphate pesticide (OPCs) in the world. Several studies suggest that organophosphate compounds cause oxidative stress and lipid peroxidation.
Materials and methods: This study was performed on male Wistar rats weighing 200-250gr. The animals were randomly divided into 15 groups. Then, IP injection of diazinon, L-carnitine, and selenium was done for four weeks. Twenty four hours after last injection, the animals received ketamine anesthesia and liver tissue was removed and glutathione (GSH) levels were determined using Elman method.
Results: The findings showed that diazinon decreased glutathione level, while L-carnitine in a dose-dependent manner increased GSH levels. Selenium at a dose of 0.5 mg /kg resulted in a significant increase in GSH level compared with diazinon alone (P> 0.05).
Conclusion: Selenium and L-carnitine improve the body's antioxidant status against OPCs such as diazinon. Moreover, through increasing GSH levels they could have a role in detoxification of free radicals caused by diazinon.
Type of Study: Research(Original) |
Subject:
toxicology
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
