Volume 22, Issue 98 (2-2013)
J Mazandaran Univ Med Sci 2013, 22(98): 2-7 |
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shokrzadeh M, Abedian kenari S, haghi aminjan H, Ghasemi M, Hoseini V, jeivad F, et al . Caspase 9 Promoter Polymorphisms in Gastric Cancer, Mazandaran Province. J Mazandaran Univ Med Sci 2013; 22 (98) :2-7
URL: http://jmums.mazums.ac.ir/article-1-1952-en.html
URL: http://jmums.mazums.ac.ir/article-1-1952-en.html
Mohammad Shokrzadeh 
, Saeid Abedian kenari * , Hamed Haghi aminjan , Maryam Ghasemi , Vahid Hoseini , Fereshteh Jeivad , Ahad Alizadeh , Faramarz Farzad
, Saeid Abedian kenari * , Hamed Haghi aminjan , Maryam Ghasemi , Vahid Hoseini , Fereshteh Jeivad , Ahad Alizadeh , Faramarz Farzad
Abstract: (13419 Views)
Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter could influence the gene activity and cause sensitivity to cancer.
Materials and methods: In this case-control study, 100 patients with gastric cancer and 100 normal subjects were considered for caspase 9 promoter gene polymorphism. DNA extraction was performed from white blood cells according to manufacturer protocol. PCR-RFLP was carried out to detect -712 C>T gene polymorphism. Data was analyzed using SPSS V.18 and P<0.05 was considered significant.
Results: In the present study 200 subjects including 143 men and 57 women were studied. All subject were well matched for geographic area and race. The results showed a relationship between increase in allele T and gastric cancer (P= 0.095 r=0.0224).
Conclusion: Screening of -712C>T caspase 9 polymorphism could be a marker in personal sensitivity to gastric cancer and useful in cancer treatment and prevention process.
Keywords: Caspase 9 promoter, gastric cancer, genetic polymorphism, PCR, Restriction fragment length polymorphism, RFLP-PCR
Type of Study: Research(Original) |
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