Volume 35, Issue 254 (3-2026)
J Mazandaran Univ Med Sci 2026, 35(254): 15-25 |
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Hosseini A, Yousofpour M, Zaker F, Azadeh H, Bijani A, Khoshnazar M, et al . Investigating the Effect of a Topical Ointment Prepared from the Ferfion Plant (Euphorbia macroclada Boiss.) on Clinical Symptoms in Patients with Primary Knee Osteoarthritis: A Double-Blind Randomized Clinical Trial. J Mazandaran Univ Med Sci 2026; 35 (254) :15-25
URL: http://jmums.mazums.ac.ir/article-1-20803-en.html
URL: http://jmums.mazums.ac.ir/article-1-20803-en.html
Amirsaeed Hosseini 
, Mohammad Yousofpour , Faranak Zaker , Hossein Azadeh , Ali Bijani , Maryam Khoshnazar , Maedeh Bagheri , Moloud Fakhri
, Mohammad Yousofpour , Faranak Zaker , Hossein Azadeh , Ali Bijani , Maryam Khoshnazar , Maedeh Bagheri , Moloud Fakhri
Abstract: (106 Views)
Background and purpose: Osteoarthritis is the most common cause of knee pain and has various treatment modalities. The Ferfion plant is a significant medicinal plant in traditional medicine used worldwide. This study aimed to investigate the effect of Ferfion herbal ointment on the clinical symptoms of patients with primary knee osteoarthritis.
Materials and methods: This double-blind, randomized clinical trial was conducted on 50 patients with primary knee osteoarthritis at Baghban Clinic. Patients were divided into two groups of 25, receiving either Ferfion ointment or a placebo. The first group received standard drug treatment plus topical Ferfion ointment, and the second group received standard drug treatment plus a placebo ointment. Drug treatment included celecoxib 100 mg capsules and one omega-3 tablet daily. Patients' symptoms were assessed at baseline, two weeks, and four weeks after treatment initiation. Study outcomes were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires. Data were analyzed using SPSS version 19, with a significance level of P < 0.05.
Results: At the beginning of the study, there were no significant differences between the two groups in age, height, weight, gender, body mass index, temperament, or side of the affected knee. According to the KOOS scale, patients treated with Ferfion showed greater improvement in clinical symptoms, joint stiffness, pain, activities of daily living, sports and recreational activities, and quality of life compared to the placebo group. However, this improvement was statistically significant only in the sports and recreational activities subscale (p=0.036). The WOMAC scale showed no statistically significant difference between the placebo and Ferfion groups at the end of the study.
Conclusion: The use of Ferfion ointment for four weeks significantly improved sports and recreational function in patients with primary knee osteoarthritis.
(Clinical Trials Registry Number: IRCT20210916052501N1)
Materials and methods: This double-blind, randomized clinical trial was conducted on 50 patients with primary knee osteoarthritis at Baghban Clinic. Patients were divided into two groups of 25, receiving either Ferfion ointment or a placebo. The first group received standard drug treatment plus topical Ferfion ointment, and the second group received standard drug treatment plus a placebo ointment. Drug treatment included celecoxib 100 mg capsules and one omega-3 tablet daily. Patients' symptoms were assessed at baseline, two weeks, and four weeks after treatment initiation. Study outcomes were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires. Data were analyzed using SPSS version 19, with a significance level of P < 0.05.
Results: At the beginning of the study, there were no significant differences between the two groups in age, height, weight, gender, body mass index, temperament, or side of the affected knee. According to the KOOS scale, patients treated with Ferfion showed greater improvement in clinical symptoms, joint stiffness, pain, activities of daily living, sports and recreational activities, and quality of life compared to the placebo group. However, this improvement was statistically significant only in the sports and recreational activities subscale (p=0.036). The WOMAC scale showed no statistically significant difference between the placebo and Ferfion groups at the end of the study.
Conclusion: The use of Ferfion ointment for four weeks significantly improved sports and recreational function in patients with primary knee osteoarthritis.
(Clinical Trials Registry Number: IRCT20210916052501N1)
Type of Study: Research(Original) |
Subject:
Pharmacognosy
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