Volume 35, Issue 254 (3-2026)
J Mazandaran Univ Med Sci 2026, 35(254): 3-14 |
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Fahim M, Cheragh-birjandi S, Yaghoubi A, Rezaei V, Dahmardeh M. The Effect of Aerobic Training on Aβ42, RAGE, and LRP-1 Gene Expression in Animal model of Streptozotocin-Induced Alzheimer’s Disease. J Mazandaran Univ Med Sci 2026; 35 (254) :3-14
URL: http://jmums.mazums.ac.ir/article-1-22621-en.html
URL: http://jmums.mazums.ac.ir/article-1-22621-en.html
Abstract: (327 Views)
Background and purpose: The accumulation of amyloid beta (Aβ) in the hippocampus is a key pathological event in the initiation and progression of Alzheimer’s disease. Aβ levels in the brain are regulated by the receptors RAGE and LRP-1. Therefore, the aim of the present study was to investigate the effect of aerobic training on Aβ42, RAGE, and LRP-1 expression in the hippocampus of streptozotocin (STZ)-induced Alzheimer’s disease rat models.
Materials and methods: Thirty male Wistar rats were randomly divided into three groups (n = 10 per group): healthy control, Alzheimer, and Alzheimer + aerobic training. The Alzheimer’s model was induced by intraventricular (ICV) injection of STZ. The aerobic training protocol was performed five sessions per week for eight weeks at a speed of 26 m/min on a treadmill. Memory was assessed using the shuttle box test. Protein expression levels of Aβ42, LRP-1, and RAGE in hippocampal tissue were measured using Western blotting. Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test.
Results: The expression levels of Aβ42 and RAGE in the hippocampus of the Alzheimer’s control group were significantly higher than those in the healthy control group (P = 0.001). Aβ42 expression was significantly lower in the Alzheimer + aerobic training group compared to the Alzheimer’s group (P = 0.016), while the reduction in hippocampal RAGE expression in the Alzheimer + aerobic training group compared to the Alzheimer’s group was not statistically significant (P = 0.521). The expression levels of LRP-1 in the hippocampus of the Alzheimer’s group were significantly lower than those in the healthy control group (P = 0.003). Moreover, LRP-1 expression in the Alzheimer + aerobic training group was significantly higher than in the Alzheimer’s control group (P = 0.036).
Conclusion: Aerobic training, by reducing RAGE expression and increasing LRP-1 levels in the hippocampus, decreases hippocampal Aβ42 accumulation, leading to improvements in memory function. Therefore, aerobic training represents a non-pharmacological strategy to modulate disease progression and should be considered in the management of Alzheimer’s disease
Materials and methods: Thirty male Wistar rats were randomly divided into three groups (n = 10 per group): healthy control, Alzheimer, and Alzheimer + aerobic training. The Alzheimer’s model was induced by intraventricular (ICV) injection of STZ. The aerobic training protocol was performed five sessions per week for eight weeks at a speed of 26 m/min on a treadmill. Memory was assessed using the shuttle box test. Protein expression levels of Aβ42, LRP-1, and RAGE in hippocampal tissue were measured using Western blotting. Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test.
Results: The expression levels of Aβ42 and RAGE in the hippocampus of the Alzheimer’s control group were significantly higher than those in the healthy control group (P = 0.001). Aβ42 expression was significantly lower in the Alzheimer + aerobic training group compared to the Alzheimer’s group (P = 0.016), while the reduction in hippocampal RAGE expression in the Alzheimer + aerobic training group compared to the Alzheimer’s group was not statistically significant (P = 0.521). The expression levels of LRP-1 in the hippocampus of the Alzheimer’s group were significantly lower than those in the healthy control group (P = 0.003). Moreover, LRP-1 expression in the Alzheimer + aerobic training group was significantly higher than in the Alzheimer’s control group (P = 0.036).
Conclusion: Aerobic training, by reducing RAGE expression and increasing LRP-1 levels in the hippocampus, decreases hippocampal Aβ42 accumulation, leading to improvements in memory function. Therefore, aerobic training represents a non-pharmacological strategy to modulate disease progression and should be considered in the management of Alzheimer’s disease
Type of Study: Research(Original) |
Subject:
Sport Physiology
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