Effects of Gabapentin on Postoperative Pain Following Laparoscopic Cholecystectomy - Journal of Mazandaran University of Medical Sciences
Volume 23, Number 103 (8-2013)                   J Mazandaran Univ Med Sci 2013, 23(103): 28-31 | Back to browse issues page


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Amri Maleh P, Alijanpour E, Nickbakhsh N, Modarress R, Naghshineh A, Esmaeili M. Effects of Gabapentin on Postoperative Pain Following Laparoscopic Cholecystectomy. J Mazandaran Univ Med Sci. 2013; 23 (103) :28-31
URL: http://jmums.mazums.ac.ir/article-1-2502-en.html

Abstract:   (16831 Views)
Background and purpose: Postoperative pain is the most common problem after elective laparoscopic cholecystectomy. This study assessed the effect of gabapentin on postoperative pain after laparoscopic cholecystectomy. Materials and methods: In this study 80 patients aged 20-60 (ASA class I, II) who were candidates for laparoscopic cholecystectomy were randomized into two groups to receive gabapentin 600 mg (n=40) and placebo (n=40). The pain was evaluated by a visual analogue scale (VAS) at 2, 4, 6, 8, 12, 18, and 24 hour post operation. Intravenous morphine was administrated to treat postoperative pain on VAS>3. Morphine consumption and pain scores were recorded. Results: The means of intravenous morphine consumption were 2.5 ± 2.6 mg and 2.7 ± 2.7 mg in the gabapentin group and the placebo group, respectively which showed no significant difference between the two groups (P>0.05). We also found no significant difference in the average pain score of the two groups in the first 24 hours after surgery (P>0.05). Conclusion: According to this study, the analgesic effect of gabapentin at a single dose of 600 mg before laparoscopic cholecystectomy is not obvious, so we recommend it at repeated and higher doses.
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Type of Study: Research(Original) | Subject: Orthopedic & Traumatology

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