Rupani M A, Banihashem N, Alijanpour E, Hasannasab B. Assesment of tracheal intubating conditions using propofol , meperidine and low doses of remifentanil. J Mazandaran Univ Med Sci 2014; 24 (112) :60-65
URL:
http://jmums.mazums.ac.ir/article-1-2971-en.html
Abstract: (8025 Views)
Background and purpose: Administration of high dose of remifentanil and propofol provides adequate coditions for tracheal intubation without musclerelaxants. Intubating conditions with meperidine, propofol and low doses of remifentanilcompared in this study.
Materials and methods: After premedication withmidazolam 0.03 mg/kg and meperidine1mg/kg, 60 patients under orthopedic surgeryrandomized equally to one of two study groups, each receiving the following: remifentanil 1 (Group I) or 1.5 µg/kg (Group II). remifentanilwas injected, anesthesia was induced withpropofol 2mg/kg. Ninety seconds after the administration of propofol, laryngoscopy and intubation were attemped. Intubation conditions were assessed as excellent,good or poor to ease of laryngoscopy, vocal cord position, coughing and jaw relaxation.
Results: There were no significant differences in the assessments of intubating conditions between the two groups(P=0.56). Compared with the baseline levels, the decrease in mean arterial pressure and heart rate were significant in two groups after anesthetic induction and endotracheal intubation(P<0.001). No patient needed treatment for hypotention or bradycardia.
Conclusion: Our results show that meperidine , low doses of remifentanyl(1-1.5µg/kg) and propofol provided excellent or good conditions for tracheal intubation in healthy patients.