Volume 10, Issue 28 (Sep 2000)                   J Mazandaran Univ Med Sci 2000, 10(28): 13-23 | Back to browse issues page

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Nikravesh M, Jalali M. To Study The Effect of Fetal Brain Drived Extract On Lesions of Hypoglossal nerve neuclei in rat. . J Mazandaran Univ Med Sci. 2000; 10 (28) :13-23
URL: http://jmums.mazums.ac.ir/article-1-306-en.html
Abstract:   (10252 Views)
Background and purpose: Lesion on neural fiber is a phenomenon which can lead to cell death of the relevant functional neurons through a retrograde degeneration. Ïn order to show the probable effect of existing trophic factors present in immature brain (fetus) in maintaining and existence of mature motor neurons, this study was conducted experimentally on animals.
Materials and Methods: Ïn this study we transected the hypoglossal nerve in 12 males wistar rat of 2 months old. The rats were divided into two, Çontrol and experimental groups. They were injected with 0.1 ml of fetal brain extract daily for 14 days. Ând in the same way the control group received normal saline. Âfter two weeks all the rats were anesthetized and perfused with formalin (10%). Âfter fixation, the brain stem of all rats were dissected, processed and serially sectioned (with 5 micron thickness), stained and then pericaryon of neurons of hypoglossal neucleus were counted and compared the unoperated and operated side in all the cases.
Results: The result of this research showed that there was considerable reduction of the number of the neurons in the nuclei of the hypoglossal which had lesions in the control group as compare to the experimental group.
Çonclusion: This result indicates that in spite of disconnection of axonal neurons with the target organ in the experimental group probably via proximal end of transected nerves, and through axonal transport, fetal brain drived trophic factors, transport to pericaryons of neurons and therefore prevent them from neuronal death in experimental group.
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Type of Study: Research(Original) |

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