Volume 24, Issue 111 (4-2014)                   J Mazandaran Univ Med Sci 2014, 24(111): 44-51 | Back to browse issues page

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Fathi N, Hosseini S, Tavakkol H, Khodadady A, Tabesh H. Effect of Oral Magnesium Citrate Supplement on Lung Function and Magnesium Level in Patients with Asthma . J Mazandaran Univ Med Sci. 2014; 24 (111) :44-51
URL: http://jmums.mazums.ac.ir/article-1-3793-en.html
Abstract:   (17555 Views)
Background and purpose: Asthma is a chronic inflammatory disorder of the airway associated with airway hyper responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing. Low dietary magnesium (Mg) could influence the occurrence and management of asthma. Mg is an essential element of human body, but its benefit for pulmonary function is not completely known. Material and Methods: This randomized, double-blind, placebo controlled, clinical trial was performed on 112 patients with mild and moderate persistent asthma. The diagnosis was based on clinical history and spirometric pulmonary testing. Blood samples were taken and level magnesium was measured. Participants were randomly assigned to consume either 340 mg of Mg as Mg citrate per day or placebo for two months. Each outcome was compared within treatment groups by paired t test for parametric data and the Wilcoxon signed rank test for non-parametric data. The significance level was considered as P<0.05. Results: After two months administration of oral Mg supplementation, significant changes were observed in FVC (P=0.002), FEV1 (P=0.000), FEV1/FVC ratio (P=0.000). The FVC, FEV1 have increased and the FEV1/FVC ratio value has decreased significantly. Conclusions: This study provides evidence that oral magnesium supplementation can improve lung function in patients with mild and moderate asthma
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Type of Study: Research(Original) | Subject: Immunology

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