Volume 19, Issue 73 (Sep 2009)                   J Mazandaran Univ Med Sci 2009, 19(73): 80-83 | Back to browse issues page

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Kazemi Arababadi M, Pourfathollah A, Hassanshahi G, Pooladvand V, Yaghini N, Shamsyzadeh A. Evaluation of serum level of IL-12 in patients withoccult HBV infection. J Mazandaran Univ Med Sci. 2009; 19 (73) :80-83
URL: http://jmums.mazums.ac.ir/article-1-592-en.html
Abstract:   (10785 Views)
Background and purpose:Occult hepatitis B infection (OBI) is a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients.
Materials and methods:In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls.
Results:Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls.
Conclusion:In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV.
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Type of Study: Research(Original) |

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