Left Ventricular Diastolic Function after Anthracycline Chemotherapy - Journal of Mazandaran University of Medical Sciences
Volume 25, Number 134 (3-2016)                   J Mazandaran Univ Med Sci 2016, 25(134): 12-19 | Back to browse issues page


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Nabati M, Janbabai G, Faghihinia M, Borhani S. Left Ventricular Diastolic Function after Anthracycline Chemotherapy . J Mazandaran Univ Med Sci. 2016; 25 (134) :12-19
URL: http://jmums.mazums.ac.ir/article-1-7198-en.html

Abstract:   (1866 Views)

Background and purpose: Anthracycline is a topoisomerase-interacting agent that is used in treatment of many cancers. We investigated the effects of anthracycline in adults using conventional echocardiography and pulse tissue Doppler imaging.

Materials and methods: This observational before-after study was performed in 35 patients being recently diagnosed with cancer for whom ANT therapy was planned. Echocardiography studies were performed before chemotherapy and 6 months after initiation of the study. Additionally, troponin I and creatinine kinase-MB (CK-MB) were measured one month after the initiation of chemotherapy.

Results: Six months after anthracycline therapy, Changes were seen in the systolic and diastolic left ventricular (LV) function. LV ejection fraction significantly decreased (P <0.001). Additionally, LV end-diastolic volume, LV end-systolic volume and left atrial diameter significantly increased compared with the baseline measures. According to the tissue Doppler imaging, the mitral annuli early diastolic (e') velocity significantly reduced, and the E/e' ratio (the peak early diastolic velocity) significantly increased.

Conclusion: Altered LV systolic and diastolic function was observed after anthracycline chemotherapy.

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Type of Study: Research(Original) | Subject: Cardiovascular

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