Volume 22, Issue 87 (Apr 2012)                   J Mazandaran Univ Med Sci 2012, 22(87): 22-28 | Back to browse issues page

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Seyed Ali Roteh S M, Tahmasebi Fard Z, Abdirad A, Moeini Z. Analysis of Ovarian Epithelial Tumors for Presence of Human Papillomavirus. J Mazandaran Univ Med Sci. 2012; 22 (87) :22-28
URL: http://jmums.mazums.ac.ir/article-1-804-en.html
Abstract:   (18974 Views)
Background and purpose: Ovarian tumor is a common neoplasm of the female genital tract and one of the most lethal gynecologic malignancies. The etiology of ovarian cancer remains unclear. Oncogenic viruses can contribute in different stages of the carcinogenic process. Papilloma viruses are Oncogenic viruses that could induce proliferation of epithelial cells. Materials and methods: In this study samples were 50 Paraffin-embedded blocks of ovarian carcinoma tissue and 58 normal Paraffin-embedded blocks (without malignancy) as control group. After DNA extraction, all samples were analyzed to detect beta-globin gene and suitable samples were screened for presence of L1 HPV-Common. The data was analyzed using one-way ANOVA in SPSS 15. Results: All positive samples for beta-globin gene were amplified by HPV-common primers. Among the samples seven of 44 (15.90%) ovarian carcinoma and five of 50 (10%) normal ovarian tissue were found positive for the common marker of HPV. Overall, 12 of 94 samples were positive (12.76%). The correlation between HPV infection and ovarian cancer was not statistically significant (p= 0.397). Conclusion: No significant correlation was found between HPV infection and ovarian cancer. Therefore, the results of this study do not confirm the role of HPV in ovarian cancer.
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Type of Study: Research(Original) |

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