Volume 26, Issue 141 (10-2016)                   J Mazandaran Univ Med Sci 2016, 26(141): 137-142 | Back to browse issues page

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Sarvar F, Nekoeian R, Saei rad S, Gharavi M J, Tehrani M, Sarvar Taherabadi M, et al . Evaluating the Most Common Mutation in BRCAI and BRCA2 Genes in Women Who had Mothers with Brest Cancer and Controls. J Mazandaran Univ Med Sci. 2016; 26 (141) :137-142
URL: http://jmums.mazums.ac.ir/article-1-8595-en.html
Abstract:   (5276 Views)

Background and purpose: Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer.

Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of genomic mutations in BRCA1 and BRCA2, genes mutation analysis was done in BRCA1 (exon2, 20) and BRCA2 (exon11) using Real Time PCR test. We also studied 109 healthy controls without family history of breast cancer.

Results: No any mutation was found in this population.

Conclusion: This study showed no mutation in affected and control group. Therefore, other mutations and genes may have a role in breast cancer pathogenesis in our population.

Full-Text [PDF 573 kb]   (1587 Downloads)    
Type of Study: Brief Report |

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