---

Background and purpose: Individuals treat the Internet phenomenon differently based on their personalities. Also, personality can predispose individuals for some psychological disorders. Some psychologists state that personality comes from nervous system functions, therefore, this study investigated the personality characteristics caused by brain-behavioral systems and gender on Internet addiction. Materials and methods: This casual-comparison research was performed in 225 people selected through cluster sampling from Internet cafes, libraries and gyms’ clients in Isfahan. The data was collected using Young’s Internet addiction scale and Gray-Wilson Personality Questionnaire. Results: Multivariate Variance Analysis (MANOVA) showed significant differences in brain-behavioral systems of addicted and non-addicted groups. Paired-test showed that these differences were due to differences in passive avoidance, and fight and flight subscales. Independent sample t-test also showed significant differences in Internet addiction between male and female. Moreover, multiple regression analysis confirmed the predicting role of passive avoidance and gender in Internet addiction. Conclusion: Behavioral inhibition system sensitivity could influence the risk factors of internet addiction. This is probably caused by enjoying the nature of Internet activities and delay in the negative outcomes at the same time. These are pleasant for individuals with high behavioral inhibition system sensitivity. Furthermore, males are more prone to Internet addiction that is due to more tendencies to develop social relations and gaining less family support than females.

---

---

Background and purpose: Angiogenesis provides proper nutrition and helps to the development and spread of cancer cells. Cancer stem cells are a rare population of tumor cells responsible for initiation, spreading and growth of cancer. Angiogenesis occurs more in cancer stem cells compared with other cancer cells. Ibuprofen, as a member of nonsteroidal anti-inflammatory drugs (NSAIDs) group is used for prevention and treatment of certain cancers. In the present study, we investigated the effect of ibuprofen on angiogenesis in gastric cancer stem cells.

Materials and methods: Gastric cancer stem cells of MKN45 cell line was isolated by spheroid colony formation technique. Gastric cancer stem cells were treated with various concentrations of ibuprofen. The angiogenic properties in gastric cancer stem cells treated with ibuprofen was compared with control cells using two-dimensional angiogenesis.

Results: Angiogenesis reduced in the cancer stem cells treated with ibuprofen compared with the control cancer stem cells.

Conclusion: Ibuprofen decreased angiogenesis in gastric cancer stem cells.